Erosion protection comparison of stabilised SnF2 , mixed fluoride active and SMFP/arginine-containing dentifrices

Int Dent J. 2014 Mar;64 Suppl 1(Suppl 1):22-8. doi: 10.1111/idj.12099.

Abstract

Purpose: To investigate the relative erosion protection potential of marketed dentifrices formulated with either stabilised stannous fluoride (SnF2 ), sodium fluoride (NaF) and/or sodium monofluorophosphate (SMFP) using an established laboratory erosion cycling model.

Methods: Sound enamel cores from extracted, human enamel were cleaned, ground and polished, soaked in pooled saliva (pellicle formation) and treated with a 1:3 slurry of dentifrice and saliva. Specimens were subjected to daily challenges with 1% citric acid, a potentially damaging acid found in common food and drinks. Marketed dentifrices compared were: (1) a stabilised stannous fluoride product formulated with 1,100 ppm F as SnF2 ; (2) a cavity protection product containing 1,100 ppm F as NaF; (3) a cavity protection product comprising a mixed active fluoride system with 1,000 ppm F as SMFP + 450 ppm F as NaF; and (4) a sensitivity product containing 1,450 ppm F as SMFP + 8% arginine bicarbonate.

Results: Specimens from Group 1 demonstrated an average loss of 5.5 (±1.2) μm of tooth surface enamel; Groups 2, 3 and 4 lost an average of 18.3 (±0.9) μm, 16.0 (±2.0) μm and 17.1 (±1.1) μm, respectively, of tooth surface enamel. Group 1 provided a statistically significant difference in protection compared with the other products.

Conclusions: These results suggest that the marketed dentifrice formulated with stabilised SnF2 may provide enhanced protection of exposed tooth surfaces against dietary acid attack compared with the other products tested.

Keywords: Erosion; arginine bicarbonate; dentifrice; fluoride; mixed fluoride; stannous fluoride.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arginine / therapeutic use*
  • Citric Acid / adverse effects
  • Complex Mixtures / therapeutic use
  • Dental Enamel / drug effects
  • Dental Enamel / ultrastructure
  • Dental Pellicle / physiology
  • Dentifrices / therapeutic use*
  • Fluorides / therapeutic use*
  • Humans
  • Hydrogen-Ion Concentration
  • Microradiography / methods
  • Phosphates / therapeutic use*
  • Potassium Compounds / therapeutic use
  • Protective Agents / therapeutic use
  • Saliva / physiology
  • Silicic Acid / therapeutic use
  • Sodium Fluoride / therapeutic use*
  • Tin Fluorides / therapeutic use*
  • Tooth Erosion / pathology
  • Tooth Erosion / prevention & control*
  • Toothpastes / therapeutic use

Substances

  • Complex Mixtures
  • Crest Pro-Health Dentifrice
  • Dentifrices
  • Phosphates
  • Potassium Compounds
  • Protective Agents
  • Tin Fluorides
  • Toothpastes
  • colgate sensitive
  • hydrated silica gel-based toothpaste
  • Silicic Acid
  • fluorophosphate
  • Citric Acid
  • Sodium Fluoride
  • Arginine
  • Fluorides