Possible neurotransmitter basis of behavioral changes in Alzheimer's disease

Ann Neurol. 1988 Jun;23(6):616-20. doi: 10.1002/ana.410230616.


Serotonin, 5-hydroxyindoleacetic acid, and homovanillic acid concentrations have been determined in 10 areas of the cerebral cortex from 17 subjects with Alzheimer's disease and 18 control subjects. The dopamine metabolite was not reduced in any area, whereas both indoleamines were reduced in the superior frontal, inferior temporal, and fusiform gyri, and the temporal pole. These areas and areas of the parietal cortex, where there were no changes in concentration, have not previously been reported on. We argue that the large loss of indoleamines from the frontal lobe (to 50-63% of control values) is rather unexpected based on other biochemical measurements and may relate to behavioral changes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholine / analysis
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / psychology
  • Cerebral Cortex / analysis*
  • Homovanillic Acid / analysis
  • Humans
  • Hydroxyindoleacetic Acid / analysis
  • Middle Aged
  • Neurotransmitter Agents / analysis*
  • Reference Values
  • Serotonin / analysis
  • Somatostatin / analysis
  • gamma-Aminobutyric Acid / analysis


  • Neurotransmitter Agents
  • Serotonin
  • Somatostatin
  • Hydroxyindoleacetic Acid
  • gamma-Aminobutyric Acid
  • Acetylcholine
  • Homovanillic Acid