Human angiogenin, an organogenic protein

Br J Cancer. 1988 Jun;57(6):587-90. doi: 10.1038/bjc.1988.133.

Abstract

Angiogenin is a 14 kD protein, initially isolated as a tumour-cell secreted product but subsequently found to be a normal constituent of human plasma. It is a potent inducer of blood vessel formation on the chorioallantoic membrane of the chick embryo. Chemical characterization of the protein reveals a remarkable homology to the pancreatic ribonuclease family and has led to the identification of a unique ribonucleolytic activity for angiogenin. It is a particularly potent inhibitor of in vitro protein synthesis. Treatment with placental ribonuclease inhibitor abolishes the biological and enzymatic activities of angiogenin, an effect with important mechanistic, physiological and pharmacologic implications.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Chemical Phenomena
  • Chemistry
  • Humans
  • Molecular Sequence Data
  • Neoplasm Proteins / blood
  • Neoplasm Proteins / isolation & purification*
  • Neoplasm Proteins / pharmacology
  • Neovascularization, Pathologic / physiopathology
  • Placental Hormones / pharmacology
  • Protein Biosynthesis
  • Ribonuclease, Pancreatic*
  • Ribonucleases / analysis
  • Ribonucleases / antagonists & inhibitors
  • Tumor Cells, Cultured / metabolism

Substances

  • Neoplasm Proteins
  • Placental Hormones
  • placental ribonuclease inhibitor
  • Ribonucleases
  • angiogenin
  • Ribonuclease, Pancreatic