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, 3 (9), 1398-403

Enhanced Intracellular siRNA Delivery Using Bioreducible Lipid-Like Nanoparticles

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Enhanced Intracellular siRNA Delivery Using Bioreducible Lipid-Like Nanoparticles

Ming Wang et al. Adv Healthc Mater.

Abstract

A new library of lipid-like nanoparticles (lipidoids) comprising disulfide bond is developed for siRNA delivery. Bioreducible lipidoids deliver siRNA with greater efficiency than nonbioreducible lipidoids with similar chemical structures. A siRNA release investigation, as well as an intracellular siRNA trafficking study, reveals that the degradation of bioreducible lipidoid in a strongly reductive intracellular environment boosts siRNA release and enhances siRNA gene knockdown efficiency.

Keywords: bioreducible lipidoid; cancer therapy; combinatorial; nanoparticles; siRNA delivery.

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