Abstract
Control of pH gradient profile at the electrode-electrolyte interfaces allows the control of the enzymatic PEG-hydrogel polymerization. By tuning the solution pH, buffer capacity, and the applied current, the extent of the local inhibition and confinement of the Factor XIII-mediated polymerization of PEG are controlled. This technology opens new perspectives for the production of 3D-structured biological microenvironments.
Keywords:
PEG-hydrogels; electrochemistry; microenvironment.
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biocompatible Materials / chemistry*
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Biocompatible Materials / metabolism
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Cell Engineering / methods*
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Cell Line
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Cellular Microenvironment
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Dimethylpolysiloxanes / chemistry
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Electrochemical Techniques / methods*
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Humans
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Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry*
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Hydrogel, Polyethylene Glycol Dimethacrylate / metabolism
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Hydrogen-Ion Concentration
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Polyethylene Glycols / chemistry*
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Polyethylene Glycols / metabolism
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Polymerization
Substances
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Biocompatible Materials
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Dimethylpolysiloxanes
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Hydrogel, Polyethylene Glycol Dimethacrylate
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Polyethylene Glycols
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baysilon