Long-term pretreatment with proton pump inhibitor and Helicobacter pylori eradication rates

World J Gastroenterol. 2014 Jan 28;20(4):1061-6. doi: 10.3748/wjg.v20.i4.1061.


Aim: To investigate whether proton pump inhibitor (PPI) pretreatment influences Helicobacter pylori eradication rate.

Methods: We retrospectively reviewed H. pylori-infected patients who were treated with a standard triple regimen (PPI, amoxicillin 1 g, and clarithromycin 500 mg, all twice daily for 7 d). The diagnosis of H. pylori infection and its eradication was assessed with the rapid urease test, histological examination by silver staining, or the ¹³C-urea breath test. We divided the patients into two groups: one received the standard eradication regimen without PPI pretreatment (Group A), and the other received PPI pretreatment (Group B). The patients in Group B were reclassified into three groups based on the duration of PPI pretreatment: Group B-I (3-14 d), Group B-II (15-55 d), and Group B-III (≥ 56 d).

Results: A total of 1090 patients were analyzed and the overall eradication rate was 80.9%. The cure rate in Group B (81.2%, 420/517) was not significantly different from that in Group A (79.2%, 454/573). The eradication rates in Group B-I, B-II and B-III were 80.1% (117/146), 81.8% (224/274) and 81.4% (79/97), respectively.

Conclusion: PPI pretreatment did not affect H. pylori eradication rate, regardless of the medication period.

Keywords: Antibiotics; Drug resistance; Helicobacter pylori; Proton pump inhibitor; Urea breath test.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Bacterial Agents / administration & dosage*
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Female
  • Helicobacter Infections / diagnosis
  • Helicobacter Infections / drug therapy*
  • Helicobacter Infections / microbiology
  • Helicobacter pylori / drug effects*
  • Helicobacter pylori / pathogenicity
  • Humans
  • Male
  • Middle Aged
  • Proton Pump Inhibitors / administration & dosage*
  • Retrospective Studies
  • Time Factors
  • Treatment Outcome


  • Anti-Bacterial Agents
  • Proton Pump Inhibitors