Paraoxon-induced desensitization and its reversal by tetrodotoxin

A L Gardner; L K Choo; F Mitchelson

doi:10.1016/0306-3623(88)90168-1

Paraoxon-induced desensitization and its reversal by tetrodotoxin

Gen Pharmacol. 1988;19(4):583-8. doi: 10.1016/0306-3623(88)90168-1.

Authors

A L Gardner¹, L K Choo, F Mitchelson

Affiliation

¹ School of Pharmacology, Victorian College of Pharmacy, Melbourne, Australia.

PMID: 2457538
DOI: 10.1016/0306-3623(88)90168-1

Abstract

1. Paraoxon (10 microM for 20 min) induced a desensitization of the taenia caecum of the guinea-pig for contractions produced by a number of cholinomimetics. 2. Tetrodotoxin (0.3 microM) reversed the desensitization suggesting involvement of Na+ channels.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Carbachol / pharmacology
Guinea Pigs
Ion Channels / metabolism
Paraoxon / pharmacology*
Pilocarpine / pharmacology
Pyrrolidines / pharmacology
Sodium / metabolism
Tetrodotoxin / pharmacology*

Substances

Ion Channels
Pyrrolidines
Pilocarpine
Tetrodotoxin
N-benzyl-3-pyrrolidylacetate methobromide
Carbachol
Sodium
Paraoxon