Endometrial carcinoma in women aged 40 years and younger

Arch Pathol Lab Med. 2014 Mar;138(3):335-42. doi: 10.5858/arpa.2012-0654-RA.


Context: Endometrial carcinoma is a disease of older postmenopausal women, and is relatively uncommon in patients younger than 40 years. Endometrial carcinomas in this age group may be familial, associated with Lynch syndrome, or sporadic.

Objectives: To present our current knowledge of endometrial carcinomas in women younger than 40 years.

Data sources: The review is based on previously published articles on this topic.

Conclusions: Most endometrial carcinomas that occur in this age group are associated with estrogen excess. They are usually low-grade endometrioid carcinomas that present at low stages and are associated with favorable clinical outcomes. Tumors associated with mismatch repair abnormalities and Lynch syndrome appear to be distinct, with worse prognostic factors and, possibly, clinical behavior. Conservative hormonal therapy and ovarian conservation are reasonable considerations in the management of these young patients, but carry the risk of tumor progression, recurrence, and an occult synchronous or metachronous ovarian carcinoma.

Publication types

  • Review

MeSH terms

  • Adult
  • Carcinoma, Endometrioid / genetics
  • Carcinoma, Endometrioid / pathology*
  • Colorectal Neoplasms, Hereditary Nonpolyposis / genetics
  • Colorectal Neoplasms, Hereditary Nonpolyposis / pathology*
  • DNA Mismatch Repair
  • Endometrial Neoplasms / genetics
  • Endometrial Neoplasms / pathology*
  • Female
  • Humans
  • Prognosis