SIK2 regulates insulin secretion

Nat Cell Biol. 2014 Mar;16(3):210-2. doi: 10.1038/ncb2925.


Correct regulation of insulin secretion by the pancreas is crucial for organismal function and survival. The AMPK-related kinase SIK2 (salt-inducible kinase 2) is now shown to be stabilized in pancreatic β-cells following glucose stimulation, leading to improved systemic glucose homeostasis by regulating cellular calcium flux and insulin secretion.

Publication types

  • Comment

MeSH terms

  • Animals
  • Female
  • Insulin-Secreting Cells / physiology*
  • Male
  • Phosphotransferases / metabolism*
  • Protein Serine-Threonine Kinases / metabolism*
  • Ubiquitin-Protein Ligases / metabolism*


  • Cdk5r1 protein, mouse
  • PJA2 protein, mouse
  • Ubiquitin-Protein Ligases
  • Phosphotransferases
  • salt-inducible kinase-2, mouse
  • Protein Serine-Threonine Kinases