SIK2 regulates insulin secretion

Bengt-Frederik Belgardt; Markus Stoffel

doi:10.1038/ncb2925

SIK2 regulates insulin secretion

Nat Cell Biol. 2014 Mar;16(3):210-2. doi: 10.1038/ncb2925.

Authors

Bengt-Frederik Belgardt¹, Markus Stoffel¹

Affiliation

¹ Institute of Molecular Health Sciences and the Competence Centre for Systems Physiology and Metabolic Diseases, ETH Zurich, Otto-Stern-Weg 7, 8093 Zurich, Switzerland.

PMID: 24576898
DOI: 10.1038/ncb2925

Abstract

Correct regulation of insulin secretion by the pancreas is crucial for organismal function and survival. The AMPK-related kinase SIK2 (salt-inducible kinase 2) is now shown to be stabilized in pancreatic β-cells following glucose stimulation, leading to improved systemic glucose homeostasis by regulating cellular calcium flux and insulin secretion.

Publication types

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MeSH terms

Animals
Female
Insulin-Secreting Cells / physiology*
Male
Phosphotransferases / metabolism*
Protein Serine-Threonine Kinases / metabolism*
Ubiquitin-Protein Ligases / metabolism*

Substances

Cdk5r1 protein, mouse
PJA2 protein, mouse
Ubiquitin-Protein Ligases
Phosphotransferases
salt-inducible kinase-2, mouse
Protein Serine-Threonine Kinases