Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study

Dement Geriatr Cogn Disord. 2014;38(1-2):39-45. doi: 10.1159/000357793. Epub 2014 Feb 20.


Background: The present study is an open-label extension (OLE) aimed at evaluating the effect of 100 mg/day of phosphatidylserine enriched with docosahexaenoic acid (PS-DHA) on cognitive performance in nondemented elderly individuals with memory complaints.

Methods: From the participants who completed the core study, 122 continued with a 15-week OLE. Efficacy was assessed using a computerized tool and the Clinical Global Impression of Change (CGI-C) rating scale.

Results: A significant improvement in sustained attention and memory recognition was observed in the PS-DHA naïve group, while the PS-DHA continuers maintained their cognitive status. Additionally, a significant improvement in CGI-C was observed in the naïve group.

Conclusions: The results demonstrate that consumption of 100 mg/day of PS-DHA might be associated with improving or maintaining cognitive status in elderly subjects with memory complaints.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Attention / drug effects*
  • Docosahexaenoic Acids* / administration & dosage
  • Docosahexaenoic Acids* / adverse effects
  • Drug Combinations
  • Drug Monitoring
  • Female
  • Geriatric Assessment / methods
  • Humans
  • Male
  • Memory / drug effects*
  • Memory Disorders* / diagnosis
  • Memory Disorders* / drug therapy
  • Memory Disorders* / psychology
  • Neuropsychological Tests
  • Nootropic Agents / administration & dosage
  • Nootropic Agents / adverse effects
  • Phosphatidylserines* / administration & dosage
  • Phosphatidylserines* / adverse effects
  • Psychiatric Status Rating Scales
  • Treatment Outcome


  • Drug Combinations
  • Nootropic Agents
  • Phosphatidylserines
  • Docosahexaenoic Acids