Preparation and characterization of electrospun curcumin loaded poly(2-hydroxyethyl methacrylate) nanofiber--a biomaterial for multidrug resistant organisms

J Biomed Mater Res A. 2015 Jan;103(1):16-24. doi: 10.1002/jbm.a.35138. Epub 2014 Mar 5.


Curcumin loaded poly(2-hydroxy ethyl methacrylate) p(HEMA) nanofiber were produced using electrospinning method and characterized. The nanofibrous scaffold supports good cell growth, attachment and retains its original morphology. Sustained and controlled release pattern of curcumin seen to be efficient against infectious disease caused by multidrug resistant organisms. Antibacterial activity of curcumin against Methicillin resistant staphylococcus aureus (MRSA) and extended spectrum β lactamase (ESBL) proved to be a good alternate herbal compound for antibiotics. Hence the results indicate p(HEMA) nanofiber loaded with curcumin have potential to use as patch in wound healing of infectious disease caused by multidrug resistant organisms and excellent drug delivery vessel.

Keywords: curcumin; electrospinning; multidrug resistant organism; nanofibers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials*
  • Curcumin / chemistry*
  • Drug Resistance, Multiple, Bacterial*
  • Microscopy, Electron, Scanning
  • Nanofibers*
  • Polyhydroxyethyl Methacrylate / chemistry*
  • Surface Properties
  • Thermogravimetry


  • Biocompatible Materials
  • Polyhydroxyethyl Methacrylate
  • Curcumin