The wonders of 2-deoxy-D-glucose

IUBMB Life. 2014 Feb;66(2):110-21. doi: 10.1002/iub.1251. Epub 2014 Feb 27.


Through the eons of time, out of all possible configurations, nature has selected glucose not only as a vital source of energy to sustain life but also as the molecule who's structure supplies the appropriate elements required for a cell to grow and multiply. This understanding, at least in part, explains the profound effects that the analog of glucose, 2-deoxy-d-glucose, has been shown to have on as common and widespread diseases as cancer, viral infection, aging-related morbidity, epilepsy, and others. This review is confined to summarizing some of the salient findings of this remarkable compound as they relate mainly to cancer.

Keywords: 2-deoxy-d-glucose; apoptosis; autophagy; endoplasmic reticulum stress; glycosylation; hypoxia; viral replication.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis / genetics
  • Autophagy / genetics
  • Deoxyglucose / genetics
  • Deoxyglucose / metabolism*
  • Endoplasmic Reticulum Stress / genetics*
  • Glycosylation
  • Humans
  • Hypoxia
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Virus Replication / genetics*


  • Deoxyglucose