[Research of the relationship of ubiquinone and beclin-1 and liver mitochondria]

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2013 Aug;27(4):250-2.
[Article in Chinese]


Objective: To study whether CO-Q10 can protect liver injury caused by acute on chronic liver failure (ACLF) by autophagy.

Methods: Rats were separated into three groups: control group, acute on chronic liver failure (ACLF) and intervenient group, liver tissues were observed by optical microscopy and electron microscopy. The levels of Beclin-1 expression were determined by real-time PCR. And Western Blot.

Results: Areas of necrosis detected in intervenient group were alleviated than in ACLF significantly. Most mitochondrias had been degradated in ACLF group while alive in intervenient group. Real-time PCR and Western Blot revealed level of beclin-1 in ACLF was lower than control and intervenient group.

Conclusion: Intervenient group may ameliorate rat liver injury by promoting autophagy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis Regulatory Proteins / genetics
  • Apoptosis Regulatory Proteins / metabolism*
  • Autophagy
  • Beclin-1
  • Humans
  • Liver Failure, Acute / genetics
  • Liver Failure, Acute / metabolism*
  • Liver Failure, Acute / physiopathology
  • Male
  • Mitochondria, Liver / metabolism*
  • Rats
  • Rats, Sprague-Dawley
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / metabolism


  • Apoptosis Regulatory Proteins
  • Beclin-1
  • Becn1 protein, rat
  • Ubiquinone
  • coenzyme Q10