Body weight regulation and obesity: dietary strategies to improve the metabolic profile

Annu Rev Food Sci Technol. 2014;5:39-51. doi: 10.1146/annurev-food-030212-182557.


This review discusses dietary strategies that may improve the metabolic profile and body weight regulation in obesity. Recent evidence demonstrated that long-term health effects seem to be more beneficial for low-glycemic index (GI) diets compared to high-protein diets. Still, these results need to be confirmed by other prospective cohort studies and long-term clinical trials, and the discrepancy between these study designs needs to be explored in more detail. Furthermore, the current literature is mixed with regard to the efficacy of increased meal frequency (or snacking) regimens in causing metabolic alterations, particularly in relation to body weight control. In conclusion, a growing body of evidence suggests that dietary strategies with the aim to reduce postprandial insulin response and increase fat oxidation, and that tend to restore metabolic flexibility, have a place in the prevention and treatment of obesity and associated metabolic disorders.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Body Weight*
  • Dairy Products
  • Diet*
  • Dietary Proteins / administration & dosage
  • Fatty Acids / metabolism
  • Glycemic Index
  • Humans
  • Hyperglycemia
  • Hyperinsulinism
  • Insulin Resistance
  • Meals
  • Metabolome*
  • Muscle, Skeletal / metabolism
  • Obesity* / physiopathology
  • Obesity* / prevention & control
  • Obesity* / therapy
  • Vegetables


  • Dietary Proteins
  • Fatty Acids