Nuclear pores set the speed limit for mitosis

Cell. 2014 Feb 27;156(5):868-9. doi: 10.1016/j.cell.2014.02.004.

Abstract

The spindle assembly checkpoint prevents separation of sister chromatids until each kinetochore is attached to the mitotic spindle. Rodriguez-Bravo et al. report that the nuclear pore complex scaffolds spindle assembly checkpoint signaling in interphase, providing a store of inhibitory signals that limits the speed of the subsequent mitosis.

Publication types

  • Comment

MeSH terms

  • Anaphase*
  • Cell Cycle Proteins / metabolism*
  • Humans
  • M Phase Cell Cycle Checkpoints*
  • Mad2 Proteins / metabolism*
  • Nuclear Pore / metabolism*
  • Nuclear Proteins / metabolism*

Substances

  • Cell Cycle Proteins
  • MAD1L1 protein, human
  • MAD2L1 protein, human
  • Mad2 Proteins
  • Nuclear Proteins