Activated microglia do not form functional gap junctions in vivo

J Neuroimmunol. 2014 Apr 15;269(1-2):90-3. doi: 10.1016/j.jneuroim.2014.02.005. Epub 2014 Feb 13.

Abstract

We investigated whether microglia form gap junctions with themselves, or with astrocytes, oligodendrocytes, or neurons in vivo in normal mouse brains, and in pathological conditions that induce microglial activation - brain injury and a model of Alzheimer's disease. Although microglia are in close physical proximity to glia and neurons, they do not form functional gap junctions under these pathological conditions.

Keywords: Alzheimer's disease; Astrocytes; Brain injury; Gap junctions; Microglia; Oligodendrocytes.

MeSH terms

  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / pathology
  • Animals
  • Brain Injuries / metabolism*
  • Brain Injuries / pathology
  • Gap Junctions / metabolism*
  • Gap Junctions / pathology
  • Humans
  • Mice
  • Mice, 129 Strain
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Microglia / metabolism*
  • Microglia / pathology
  • Organ Culture Techniques