Are serum suPAR determinations by current ELISA methodology reliable diagnostic biomarkers for FSGS?

Kidney Int. 2014 Mar;85(3):499-501. doi: 10.1038/ki.2013.549.

Abstract

A soluble proteinuric substance has been postulated as a cause of primary focal segmental glomerulosclerosis (FSGS), and one candidate soluble urokinase receptor (suPAR). Evaluation of published results shows that serum suPAR determinations by current methodology do not reliably distinguish FSGS from other proteinuric glomerular diseases and serum suPAR cannot currently be considered a valid biomarker for primary or secondary FSGS. However, this should not discourage further research on potential roles of suPAR in proteinuric renal disease, including FSGS.

Publication types

  • Comment

MeSH terms

  • Female
  • Glomerulonephritis / blood*
  • Glomerulosclerosis, Focal Segmental / blood*
  • Glomerulosclerosis, Focal Segmental / diagnosis*
  • Humans
  • Male
  • Nephrotic Syndrome / blood*
  • Receptors, Urokinase Plasminogen Activator / blood*
  • Receptors, Urokinase Plasminogen Activator / physiology*

Substances

  • Receptors, Urokinase Plasminogen Activator