Body mass index and risk of age-related cataract: a meta-analysis of prospective cohort studies

PLoS One. 2014 Feb 24;9(2):e89923. doi: 10.1371/journal.pone.0089923. eCollection 2014.

Abstract

Background: Age-related cataract (ARC) is the leading cause of blindness in the world. The relationship between body mass index (BMI) and risk of ARC is controversial across observational studies. We therefore performed this meta-analysis to evaluate the association between BMI and risk of ARC.

Methods: Eligible studies were identified through an electronic search of PubMed, Embase and the Cochrane Library. We pooled study-specific relative risks (RRs) and 95% confidence intervals (CIs) to determine the risk of ARC associated with BMI categories and per 1 kg/m² increase in BMI.

Results: A total of 17 prospective cohort studies were included in the meta-analysis. The pooled RRs of ARC were 1.08 (95% CI, 1.01-1.16) for overweight and 1.19 (95% CI, 1.10-1.28) for obesity compared with normal weight. These findings were robust when stratified by sex, sample source, outcome types and confounders, while significantly differed by assessment of BMI and ARC, and duration of follow-up. The summary RR suggested that per 1 kg/m² increase in BMI was associated with a 2% increased risk of ARC (RR 1.02, 95% CI 1.01-1.03). Pooled estimates of RRs consistently indicated a trend for subjects with a high BMI to develop posterior subcapsular cataracts (RR 1.19, 95% CI 1.06-1.35, for overweight; RR 1.50, 95% CI 1.24-1.81, for obesity; RR 1.04, 95% CI 1.01-1.06, per 1 kg/m² increase in BMI) other than nuclear or cortical cataracts.

Conclusions: The overall findings suggest that elevated BMI may increase the risk of ARC, especially posterior subcapsular cataracts. Further trials are needed to investigate the effect of weight reduction in obese populations on the risk of ARC.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Body Mass Index
  • Cataract / epidemiology*
  • Cataract / etiology*
  • Cohort Studies
  • Humans
  • Overweight / complications*
  • Prospective Studies

Grant support

This study was funded by: 1. Natural Science Foundation of China (No. 81070756); 2. National “Twelfth Five-Year” Plan for Science & Technology Support of China (No. 2012BAI08B01); 3. Program for New Century Excellent Talents in University, China (No. NCET-11-0161); 4. Zhejiang Provincial Program for Cultivation of High-Level Innovative Health Talents; 5. The Specialized Key Science & Technology Foundation of Zhejiang Provincial S & T Department (No. 2012C13023-2); 6. Zhejiang Provincial Key Project of Medical and Health (No. 2011ZDA014). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.