Pediatric low-grade gliomas: how modern biology reshapes the clinical field

Biochim Biophys Acta. 2014 Apr;1845(2):294-307. doi: 10.1016/j.bbcan.2014.02.004. Epub 2014 Feb 28.


Low-grade gliomas represent the most frequent brain tumors arising during childhood. They are characterized by a broad and heterogeneous group of tumors that are currently classified by the WHO according to their morphological appearance. Here we review the clinical features of these tumors, current therapeutic strategies and the recent discovery of genomic alterations characteristic to these tumors. We further explore how these recent biological findings stand to transform the treatment for these tumors and impact the diagnostic criteria for pediatric low-grade gliomas.

Keywords: BRAF; Genetics; Low-grade glioma; Pediatric.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Apoptosis / genetics
  • Brain Neoplasms / epidemiology
  • Brain Neoplasms / genetics
  • Brain Neoplasms / pathology*
  • Brain Neoplasms / therapy*
  • Cell Survival / genetics
  • Epigenesis, Genetic / genetics
  • Glioma / epidemiology
  • Glioma / genetics
  • Glioma / pathology*
  • Glioma / therapy*
  • Humans
  • Molecular Targeted Therapy
  • Neoplasm Grading
  • Pediatrics
  • Prognosis