Rice bran and raspberry seed oil-based nanocarriers with self-antioxidative properties as safe photoprotective formulations

Photochem Photobiol Sci. 2014 Apr;13(4):703-16. doi: 10.1039/c3pp50290b.


The aim of this research was to develop advanced lipid nanocarriers based on renewable vegetable resources (rice bran oil and raspberry seed oil) that possess self-antioxidative properties, having advantages in terms of minimal side effects and exhibiting the ability to simultaneously co-encapsulate and co-release two active compounds. The focus has been oriented towards developing safe cosmetic formulations with broad-spectrum photoprotection based on these new lipid nanocarriers that contain large amounts of vegetable oils and low concentrations of synthetic UVA and UVB filters (butyl-methoxydibenzoylmethane - BMDBM and octocrylene - OCT). The lipid nanocarriers have a spherical shape and show good physical stability, with a zeta potential in the range of -25.5 to -32.4 mV. Both vegetable oils play a key role in the preparation of efficient nanocarriers, leading to a less ordered arrangement of the lipid core that offers many spaces for the entrapment of large amounts of BMDBM (79%) and OCT (90%), as wells as improved antioxidant activity and UV absorption properties, particularly for the lipid nanocarriers prepared from rice bran oil. By formulating the lipid nanocarriers into creams containing only 3.5% of the UV filters and 10.5% of the vegetable oils, the resulting sunscreens exhibited improved photoprotection, reflecting up to 91% and 93% of UVA and UVB rays, respectively. A new direction of research achieved by this study is the multiple release strategy of both UV filters from the same lipid nanocarrier. After 24 hours, a slow release of BMDBM (less than 4%) and OCT (17.5%) was obtained through a Fick diffusion process. This study demonstrates a significant advance in the areas of both nanotechnology and cosmetics, developing safer cosmetic formulations that possess broad antioxidant, photoprotective and co-release effectiveness due to the existence of a high content of nanostructured vegetable oils combined with a low amount of synthetic UV filters in the same carrier system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorption, Radiation
  • Acrylates / chemistry
  • Alkanes / chemistry
  • Antioxidants / chemistry
  • Chalcones / chemistry
  • Chemistry, Pharmaceutical
  • Cosmetics / chemistry
  • Crystallization
  • Diffusion
  • Drug Stability
  • Fruit / chemistry*
  • Kinetics
  • Lipids / chemistry
  • Nanocapsules / chemistry*
  • Oryza / chemistry*
  • Particle Size
  • Photochemical Processes
  • Plant Oils / chemistry*
  • Propiophenones
  • Seeds / chemistry*
  • Sunscreening Agents / chemistry*
  • Ultraviolet Rays


  • Acrylates
  • Alkanes
  • Antioxidants
  • Chalcones
  • Cosmetics
  • Lipids
  • Nanocapsules
  • Plant Oils
  • Propiophenones
  • Sunscreening Agents
  • octocrylene
  • avobenzone