Developmental Pathway for Potent V1V2-directed HIV-neutralizing Antibodies

Nature. 2014 May 1;509(7498):55-62. doi: 10.1038/nature13036. Epub 2014 Mar 2.

Abstract

Antibodies capable of neutralizing HIV-1 often target variable regions 1 and 2 (V1V2) of the HIV-1 envelope, but the mechanism of their elicitation has been unclear. Here we define the developmental pathway by which such antibodies are generated and acquire the requisite molecular characteristics for neutralization. Twelve somatically related neutralizing antibodies (CAP256-VRC26.01-12) were isolated from donor CAP256 (from the Centre for the AIDS Programme of Research in South Africa (CAPRISA)); each antibody contained the protruding tyrosine-sulphated, anionic antigen-binding loop (complementarity-determining region (CDR) H3) characteristic of this category of antibodies. Their unmutated ancestor emerged between weeks 30-38 post-infection with a 35-residue CDR H3, and neutralized the virus that superinfected this individual 15 weeks after initial infection. Improved neutralization breadth and potency occurred by week 59 with modest affinity maturation, and was preceded by extensive diversification of the virus population. HIV-1 V1V2-directed neutralizing antibodies can thus develop relatively rapidly through initial selection of B cells with a long CDR H3, and limited subsequent somatic hypermutation. These data provide important insights relevant to HIV-1 vaccine development.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • AIDS Vaccines / chemistry
  • AIDS Vaccines / immunology
  • Amino Acid Sequence
  • Antibodies, Neutralizing / chemistry
  • Antibodies, Neutralizing / genetics
  • Antibodies, Neutralizing / immunology*
  • Antibodies, Neutralizing / isolation & purification
  • Antibody Affinity / genetics
  • Antibody Affinity / immunology
  • B-Lymphocytes / cytology
  • B-Lymphocytes / immunology
  • B-Lymphocytes / metabolism
  • Binding Sites / immunology
  • CD4 Antigens / immunology
  • CD4 Antigens / metabolism
  • Cell Lineage
  • Complementarity Determining Regions / chemistry
  • Complementarity Determining Regions / genetics
  • Complementarity Determining Regions / immunology
  • Epitope Mapping
  • Epitopes, B-Lymphocyte / chemistry
  • Epitopes, B-Lymphocyte / immunology
  • Evolution, Molecular
  • HIV Antibodies / chemistry
  • HIV Antibodies / genetics
  • HIV Antibodies / immunology*
  • HIV Antibodies / isolation & purification
  • HIV Envelope Protein gp160 / chemistry*
  • HIV Envelope Protein gp160 / immunology*
  • HIV Infections / immunology
  • HIV-1 / chemistry
  • HIV-1 / immunology
  • Humans
  • Models, Molecular
  • Molecular Sequence Data
  • Neutralization Tests
  • Protein Structure, Tertiary
  • Somatic Hypermutation, Immunoglobulin / genetics

Substances

  • AIDS Vaccines
  • Antibodies, Neutralizing
  • CD4 Antigens
  • Complementarity Determining Regions
  • Epitopes, B-Lymphocyte
  • HIV Antibodies
  • HIV Envelope Protein gp160

Associated data

  • GENBANK/KJ133708
  • GENBANK/KJ133709
  • GENBANK/KJ133710
  • GENBANK/KJ133711
  • GENBANK/KJ133712
  • GENBANK/KJ133713
  • GENBANK/KJ133714
  • GENBANK/KJ133715
  • GENBANK/KJ133716
  • GENBANK/KJ133717
  • GENBANK/KJ133718
  • GENBANK/KJ133719
  • GENBANK/KJ133720
  • GENBANK/KJ133721
  • GENBANK/KJ133722
  • GENBANK/KJ133723
  • GENBANK/KJ133724
  • GENBANK/KJ133725
  • GENBANK/KJ133726
  • GENBANK/KJ133727
  • GENBANK/KJ133728
  • GENBANK/KJ133729
  • GENBANK/KJ133730
  • GENBANK/KJ133731
  • GENBANK/KJ133732
  • GENBANK/KJ133733
  • GENBANK/KJ133734
  • GENBANK/KJ133735
  • GENBANK/KJ133736
  • GENBANK/KJ133737
  • GENBANK/KJ133738
  • GENBANK/KJ133739
  • GENBANK/KJ133740
  • GENBANK/KJ133741
  • GENBANK/KJ133742
  • GENBANK/KJ133743
  • GENBANK/KJ133744
  • GENBANK/KJ133745
  • GENBANK/KJ133746
  • GENBANK/KJ133747
  • GENBANK/KJ133748
  • GENBANK/KJ133749
  • GENBANK/KJ133750
  • GENBANK/KJ133751
  • GENBANK/KJ133752
  • GENBANK/KJ133753
  • GENBANK/KJ133754
  • GENBANK/KJ133755
  • GENBANK/KJ133756
  • GENBANK/KJ133757
  • GENBANK/KJ133758
  • GENBANK/KJ133759
  • GENBANK/KJ133760
  • GENBANK/KJ133761
  • GENBANK/KJ133762
  • GENBANK/KJ133763
  • GENBANK/KJ133764
  • GENBANK/KJ133765
  • GENBANK/KJ133766
  • GENBANK/KJ133767
  • GENBANK/KJ133768
  • GENBANK/KJ133769
  • GENBANK/KJ133770
  • GENBANK/KJ133771
  • GENBANK/KJ133772
  • GENBANK/KJ133773
  • GENBANK/KJ133774
  • GENBANK/KJ133775
  • GENBANK/KJ133776
  • GENBANK/KJ133777
  • GENBANK/KJ133778
  • GENBANK/KJ133779
  • GENBANK/KJ133780
  • GENBANK/KJ133781
  • GENBANK/KJ133782
  • GENBANK/KJ133783
  • GENBANK/KJ133784
  • GENBANK/KJ133785
  • GENBANK/KJ133786
  • GENBANK/KJ133787
  • GENBANK/KJ133788
  • GENBANK/KJ133789
  • GENBANK/KJ133790
  • GENBANK/KJ133791
  • GENBANK/KJ133792
  • GENBANK/KJ133793
  • GENBANK/KJ133794
  • GENBANK/KJ133795
  • GENBANK/KJ133796
  • GENBANK/KJ133797
  • GENBANK/KJ133798
  • GENBANK/KJ133799
  • GENBANK/KJ133800
  • GENBANK/KJ133801
  • GENBANK/KJ133802
  • GENBANK/KJ133803
  • GENBANK/KJ133804
  • GENBANK/KJ133805
  • GENBANK/KJ133806
  • GENBANK/KJ133807
  • GENBANK/KJ133808
  • GENBANK/KJ133809
  • GENBANK/KJ133810
  • GENBANK/KJ133811
  • GENBANK/KJ133812
  • GENBANK/KJ133813
  • GENBANK/KJ133814
  • GENBANK/KJ133815
  • GENBANK/KJ133816
  • GENBANK/KJ133817
  • GENBANK/KJ133818
  • GENBANK/KJ133819
  • GENBANK/KJ133820
  • GENBANK/KJ133821
  • GENBANK/KJ133822
  • GENBANK/KJ133823
  • GENBANK/KJ133824
  • GENBANK/KJ133825
  • GENBANK/KJ133826
  • GENBANK/KJ133827
  • GENBANK/KJ133828
  • GENBANK/KJ133829
  • GENBANK/KJ133830
  • GENBANK/KJ133831
  • GENBANK/KJ133832
  • GENBANK/KJ133833
  • GENBANK/KJ133834
  • GENBANK/KJ133835
  • GENBANK/KJ133836
  • GENBANK/KJ133837
  • GENBANK/KJ133838
  • GENBANK/KJ133839
  • GENBANK/KJ133840
  • GENBANK/KJ133841
  • GENBANK/KJ133842
  • GENBANK/KJ133843
  • GENBANK/KJ133844
  • GENBANK/KJ133845
  • GENBANK/KJ133846
  • GENBANK/KJ133847
  • GENBANK/KJ133848
  • GENBANK/KJ133849
  • GENBANK/KJ133850
  • GENBANK/KJ133851
  • GENBANK/KJ133852
  • GENBANK/KJ133853
  • GENBANK/KJ133854
  • GENBANK/KJ133855
  • GENBANK/KJ133856
  • GENBANK/KJ133857
  • GENBANK/KJ133858
  • GENBANK/KJ133859
  • GENBANK/KJ133860
  • GENBANK/KJ133861
  • GENBANK/KJ133862
  • GENBANK/KJ133863
  • GENBANK/KJ133864
  • GENBANK/KJ133865
  • GENBANK/KJ133866
  • GENBANK/KJ133867
  • GENBANK/KJ133868
  • GENBANK/KJ133869
  • GENBANK/KJ133870
  • GENBANK/KJ133871
  • GENBANK/KJ133872
  • GENBANK/KJ133873
  • GENBANK/KJ133874
  • GENBANK/KJ133875
  • GENBANK/KJ133876
  • GENBANK/KJ133877
  • GENBANK/KJ133878
  • GENBANK/KJ133879
  • GENBANK/KJ133880
  • GENBANK/KJ133881
  • GENBANK/KJ133882
  • GENBANK/KJ133883
  • GENBANK/KJ133884
  • GENBANK/KJ133885
  • GENBANK/KJ133886
  • GENBANK/KJ133887
  • GENBANK/KJ133888
  • GENBANK/KJ133889
  • GENBANK/KJ133890
  • GENBANK/KJ133891
  • GENBANK/KJ133892
  • GENBANK/KJ133893
  • GENBANK/KJ133894
  • GENBANK/KJ133895
  • GENBANK/KJ133896
  • GENBANK/KJ133897
  • GENBANK/KJ133898
  • GENBANK/KJ133899
  • GENBANK/KJ133900
  • GENBANK/KJ133901
  • GENBANK/KJ133902
  • GENBANK/KJ133903
  • GENBANK/KJ133904
  • GENBANK/KJ133905
  • GENBANK/KJ133906
  • GENBANK/KJ133907
  • GENBANK/KJ133908
  • GENBANK/KJ133909
  • GENBANK/KJ133910
  • GENBANK/KJ133911
  • GENBANK/KJ133912
  • GENBANK/KJ133913
  • GENBANK/KJ133914
  • GENBANK/KJ133915
  • GENBANK/KJ133916
  • GENBANK/KJ133917
  • GENBANK/KJ133918
  • GENBANK/KJ133919
  • GENBANK/KJ133920
  • GENBANK/KJ133921
  • GENBANK/KJ133922
  • GENBANK/KJ133923
  • GENBANK/KJ133924
  • GENBANK/KJ133925
  • GENBANK/KJ133926
  • GENBANK/KJ133927
  • GENBANK/KJ133928
  • GENBANK/KJ133929
  • GENBANK/KJ133930
  • GENBANK/KJ133931
  • GENBANK/KJ133932
  • GENBANK/KJ133933
  • GENBANK/KJ133934
  • GENBANK/KJ133935
  • GENBANK/KJ133936
  • GENBANK/KJ133937
  • GENBANK/KJ133938
  • GENBANK/KJ133939
  • GENBANK/KJ133940
  • GENBANK/KJ133941
  • GENBANK/KJ133942
  • GENBANK/KJ133943
  • GENBANK/KJ133944
  • GENBANK/KJ133945
  • GENBANK/KJ133946
  • GENBANK/KJ133947
  • GENBANK/KJ133948
  • GENBANK/KJ133949
  • GENBANK/KJ133950
  • GENBANK/KJ133951
  • GENBANK/KJ133952
  • GENBANK/KJ133953
  • GENBANK/KJ133954
  • GENBANK/KJ133955
  • GENBANK/KJ133956
  • GENBANK/KJ133957
  • GENBANK/KJ133958
  • GENBANK/KJ133959
  • GENBANK/KJ133960
  • GENBANK/KJ133961
  • GENBANK/KJ133962
  • GENBANK/KJ133963
  • GENBANK/KJ133964
  • GENBANK/KJ133965
  • GENBANK/KJ133966
  • GENBANK/KJ133967
  • GENBANK/KJ133968
  • GENBANK/KJ133969
  • GENBANK/KJ133970
  • GENBANK/KJ133971
  • GENBANK/KJ133972
  • GENBANK/KJ133973
  • GENBANK/KJ133974
  • GENBANK/KJ133975
  • GENBANK/KJ133976
  • GENBANK/KJ133977
  • GENBANK/KJ133978
  • GENBANK/KJ133979
  • GENBANK/KJ133980
  • GENBANK/KJ133981
  • GENBANK/KJ133982
  • GENBANK/KJ133983
  • GENBANK/KJ133984
  • GENBANK/KJ133985
  • GENBANK/KJ133986
  • GENBANK/KJ133987
  • GENBANK/KJ133988
  • GENBANK/KJ133989
  • GENBANK/KJ133990
  • GENBANK/KJ133991
  • GENBANK/KJ133992
  • GENBANK/KJ133993
  • GENBANK/KJ133994
  • GENBANK/KJ133995
  • GENBANK/KJ133996
  • GENBANK/KJ133997
  • GENBANK/KJ133998
  • GENBANK/KJ133999
  • GENBANK/KJ134000
  • GENBANK/KJ134001
  • GENBANK/KJ134002
  • GENBANK/KJ134003
  • GENBANK/KJ134004
  • GENBANK/KJ134005
  • GENBANK/KJ134006
  • GENBANK/KJ134007
  • GENBANK/KJ134008
  • GENBANK/KJ134009
  • GENBANK/KJ134010
  • GENBANK/KJ134011
  • GENBANK/KJ134012
  • GENBANK/KJ134013
  • GENBANK/KJ134014
  • GENBANK/KJ134015
  • GENBANK/KJ134016
  • GENBANK/KJ134017
  • GENBANK/KJ134018
  • GENBANK/KJ134019
  • GENBANK/KJ134020
  • GENBANK/KJ134021
  • GENBANK/KJ134022
  • GENBANK/KJ134023
  • GENBANK/KJ134024
  • GENBANK/KJ134025
  • GENBANK/KJ134026
  • GENBANK/KJ134027
  • GENBANK/KJ134028
  • GENBANK/KJ134029
  • GENBANK/KJ134030
  • GENBANK/KJ134031
  • GENBANK/KJ134032
  • GENBANK/KJ134033
  • GENBANK/KJ134034
  • GENBANK/KJ134035
  • GENBANK/KJ134036
  • GENBANK/KJ134037
  • GENBANK/KJ134038
  • GENBANK/KJ134039
  • GENBANK/KJ134040
  • GENBANK/KJ134041
  • GENBANK/KJ134042
  • GENBANK/KJ134043
  • GENBANK/KJ134044
  • GENBANK/KJ134045
  • GENBANK/KJ134046
  • GENBANK/KJ134047
  • GENBANK/KJ134048
  • GENBANK/KJ134049
  • GENBANK/KJ134050
  • GENBANK/KJ134051
  • GENBANK/KJ134052
  • GENBANK/KJ134053
  • GENBANK/KJ134054
  • GENBANK/KJ134055
  • GENBANK/KJ134056
  • GENBANK/KJ134057
  • GENBANK/KJ134058
  • GENBANK/KJ134059
  • GENBANK/KJ134060
  • GENBANK/KJ134061
  • GENBANK/KJ134062
  • GENBANK/KJ134063
  • GENBANK/KJ134064
  • GENBANK/KJ134065
  • GENBANK/KJ134066
  • GENBANK/KJ134067
  • GENBANK/KJ134068
  • GENBANK/KJ134069
  • GENBANK/KJ134070
  • GENBANK/KJ134071
  • GENBANK/KJ134072
  • GENBANK/KJ134073
  • GENBANK/KJ134074
  • GENBANK/KJ134075
  • GENBANK/KJ134076
  • GENBANK/KJ134077
  • GENBANK/KJ134078
  • GENBANK/KJ134079
  • GENBANK/KJ134080
  • GENBANK/KJ134081
  • GENBANK/KJ134082
  • GENBANK/KJ134083
  • GENBANK/KJ134084
  • GENBANK/KJ134085
  • GENBANK/KJ134086
  • GENBANK/KJ134087
  • GENBANK/KJ134088
  • GENBANK/KJ134089
  • GENBANK/KJ134090
  • GENBANK/KJ134091
  • GENBANK/KJ134092
  • GENBANK/KJ134093
  • GENBANK/KJ134094
  • GENBANK/KJ134095
  • GENBANK/KJ134096
  • GENBANK/KJ134097
  • GENBANK/KJ134098
  • GENBANK/KJ134099
  • GENBANK/KJ134100
  • GENBANK/KJ134101
  • GENBANK/KJ134102
  • GENBANK/KJ134103
  • GENBANK/KJ134104
  • GENBANK/KJ134105
  • GENBANK/KJ134106
  • GENBANK/KJ134107
  • GENBANK/KJ134108
  • GENBANK/KJ134109
  • GENBANK/KJ134110
  • GENBANK/KJ134111
  • GENBANK/KJ134112
  • GENBANK/KJ134113
  • GENBANK/KJ134114
  • GENBANK/KJ134115
  • GENBANK/KJ134116
  • GENBANK/KJ134117
  • GENBANK/KJ134118
  • GENBANK/KJ134119
  • GENBANK/KJ134120
  • GENBANK/KJ134121
  • GENBANK/KJ134122
  • GENBANK/KJ134123
  • GENBANK/KJ134124
  • GENBANK/KJ134125
  • GENBANK/KJ134126
  • GENBANK/KJ134127
  • GENBANK/KJ134128
  • GENBANK/KJ134129
  • GENBANK/KJ134130
  • GENBANK/KJ134131
  • GENBANK/KJ134132
  • GENBANK/KJ134133
  • GENBANK/KJ134134
  • GENBANK/KJ134135
  • GENBANK/KJ134136
  • GENBANK/KJ134137
  • GENBANK/KJ134138
  • GENBANK/KJ134139
  • GENBANK/KJ134140
  • GENBANK/KJ134141
  • GENBANK/KJ134142
  • GENBANK/KJ134143
  • GENBANK/KJ134144
  • GENBANK/KJ134145
  • GENBANK/KJ134146
  • GENBANK/KJ134147
  • GENBANK/KJ134148
  • GENBANK/KJ134149
  • GENBANK/KJ134150
  • GENBANK/KJ134151
  • GENBANK/KJ134152
  • GENBANK/KJ134153
  • GENBANK/KJ134154
  • GENBANK/KJ134155
  • GENBANK/KJ134156
  • GENBANK/KJ134157
  • GENBANK/KJ134158
  • GENBANK/KJ134159
  • GENBANK/KJ134160
  • GENBANK/KJ134161
  • GENBANK/KJ134162
  • GENBANK/KJ134163
  • GENBANK/KJ134164
  • GENBANK/KJ134165
  • GENBANK/KJ134166
  • GENBANK/KJ134167
  • GENBANK/KJ134168
  • GENBANK/KJ134169
  • GENBANK/KJ134170
  • GENBANK/KJ134171
  • GENBANK/KJ134172
  • GENBANK/KJ134173
  • GENBANK/KJ134174
  • GENBANK/KJ134175
  • GENBANK/KJ134176
  • GENBANK/KJ134177
  • GENBANK/KJ134178
  • GENBANK/KJ134179
  • GENBANK/KJ134180
  • GENBANK/KJ134181
  • GENBANK/KJ134182
  • GENBANK/KJ134183
  • GENBANK/KJ134184
  • GENBANK/KJ134185
  • GENBANK/KJ134186
  • GENBANK/KJ134187
  • GENBANK/KJ134188
  • GENBANK/KJ134189
  • GENBANK/KJ134190
  • GENBANK/KJ134191
  • GENBANK/KJ134192
  • GENBANK/KJ134193
  • GENBANK/KJ134194
  • GENBANK/KJ134195
  • GENBANK/KJ134196
  • GENBANK/KJ134197
  • GENBANK/KJ134198
  • GENBANK/KJ134199
  • GENBANK/KJ134200
  • GENBANK/KJ134201
  • GENBANK/KJ134202
  • GENBANK/KJ134203
  • GENBANK/KJ134204
  • GENBANK/KJ134205
  • GENBANK/KJ134206
  • GENBANK/KJ134207
  • GENBANK/KJ134208
  • GENBANK/KJ134209
  • GENBANK/KJ134210
  • GENBANK/KJ134211
  • GENBANK/KJ134212
  • GENBANK/KJ134213
  • GENBANK/KJ134214
  • GENBANK/KJ134215
  • GENBANK/KJ134216
  • GENBANK/KJ134217
  • GENBANK/KJ134218
  • GENBANK/KJ134219
  • GENBANK/KJ134220
  • GENBANK/KJ134221
  • GENBANK/KJ134222
  • GENBANK/KJ134223
  • GENBANK/KJ134224
  • GENBANK/KJ134225
  • GENBANK/KJ134226
  • GENBANK/KJ134227
  • GENBANK/KJ134228
  • GENBANK/KJ134229
  • GENBANK/KJ134230
  • GENBANK/KJ134231
  • GENBANK/KJ134232
  • GENBANK/KJ134233
  • GENBANK/KJ134234
  • GENBANK/KJ134235
  • GENBANK/KJ134236
  • GENBANK/KJ134237
  • GENBANK/KJ134238
  • GENBANK/KJ134239
  • GENBANK/KJ134240
  • GENBANK/KJ134241
  • GENBANK/KJ134242
  • GENBANK/KJ134243
  • GENBANK/KJ134244
  • GENBANK/KJ134245
  • GENBANK/KJ134246
  • GENBANK/KJ134247
  • GENBANK/KJ134248
  • GENBANK/KJ134249
  • GENBANK/KJ134250
  • GENBANK/KJ134251
  • GENBANK/KJ134252
  • GENBANK/KJ134253
  • GENBANK/KJ134254
  • GENBANK/KJ134255
  • GENBANK/KJ134256
  • GENBANK/KJ134257
  • GENBANK/KJ134258
  • GENBANK/KJ134259
  • GENBANK/KJ134260
  • GENBANK/KJ134261
  • GENBANK/KJ134262
  • GENBANK/KJ134263
  • GENBANK/KJ134264
  • GENBANK/KJ134265
  • GENBANK/KJ134266
  • GENBANK/KJ134267
  • GENBANK/KJ134268
  • GENBANK/KJ134269
  • GENBANK/KJ134270
  • GENBANK/KJ134271
  • GENBANK/KJ134272
  • GENBANK/KJ134273
  • GENBANK/KJ134274
  • GENBANK/KJ134275
  • GENBANK/KJ134276
  • GENBANK/KJ134277
  • GENBANK/KJ134278
  • GENBANK/KJ134279
  • GENBANK/KJ134280
  • GENBANK/KJ134281
  • GENBANK/KJ134282
  • GENBANK/KJ134283
  • GENBANK/KJ134284
  • GENBANK/KJ134285
  • GENBANK/KJ134286
  • GENBANK/KJ134287
  • GENBANK/KJ134288
  • GENBANK/KJ134289
  • GENBANK/KJ134290
  • GENBANK/KJ134291
  • GENBANK/KJ134292
  • GENBANK/KJ134293
  • GENBANK/KJ134294
  • GENBANK/KJ134295
  • GENBANK/KJ134296
  • GENBANK/KJ134297
  • GENBANK/KJ134298
  • GENBANK/KJ134299
  • GENBANK/KJ134300
  • GENBANK/KJ134301
  • GENBANK/KJ134302
  • GENBANK/KJ134303
  • GENBANK/KJ134304
  • GENBANK/KJ134305
  • GENBANK/KJ134306
  • GENBANK/KJ134307
  • GENBANK/KJ134308
  • GENBANK/KJ134309
  • GENBANK/KJ134310
  • GENBANK/KJ134311
  • GENBANK/KJ134312
  • GENBANK/KJ134313
  • GENBANK/KJ134314
  • GENBANK/KJ134315
  • GENBANK/KJ134316
  • GENBANK/KJ134317
  • GENBANK/KJ134318
  • GENBANK/KJ134319
  • GENBANK/KJ134320
  • GENBANK/KJ134321
  • GENBANK/KJ134322
  • GENBANK/KJ134323
  • GENBANK/KJ134324
  • GENBANK/KJ134325
  • GENBANK/KJ134326
  • GENBANK/KJ134327
  • GENBANK/KJ134328
  • GENBANK/KJ134329
  • GENBANK/KJ134330
  • GENBANK/KJ134331
  • GENBANK/KJ134332
  • GENBANK/KJ134333
  • GENBANK/KJ134334
  • GENBANK/KJ134335
  • GENBANK/KJ134336
  • GENBANK/KJ134337
  • GENBANK/KJ134338
  • GENBANK/KJ134339
  • GENBANK/KJ134340
  • GENBANK/KJ134341
  • GENBANK/KJ134342
  • GENBANK/KJ134343
  • GENBANK/KJ134344
  • GENBANK/KJ134345
  • GENBANK/KJ134346
  • GENBANK/KJ134347
  • GENBANK/KJ134348
  • GENBANK/KJ134349
  • GENBANK/KJ134350
  • GENBANK/KJ134351
  • GENBANK/KJ134352
  • GENBANK/KJ134353
  • GENBANK/KJ134354
  • GENBANK/KJ134355
  • GENBANK/KJ134356
  • GENBANK/KJ134357
  • GENBANK/KJ134358
  • GENBANK/KJ134359
  • GENBANK/KJ134360
  • GENBANK/KJ134361
  • GENBANK/KJ134362
  • GENBANK/KJ134363
  • GENBANK/KJ134364
  • GENBANK/KJ134365
  • GENBANK/KJ134366
  • GENBANK/KJ134367
  • GENBANK/KJ134368
  • GENBANK/KJ134369
  • GENBANK/KJ134370
  • GENBANK/KJ134371
  • GENBANK/KJ134372
  • GENBANK/KJ134373
  • GENBANK/KJ134374
  • GENBANK/KJ134375
  • GENBANK/KJ134376
  • GENBANK/KJ134377
  • GENBANK/KJ134378
  • GENBANK/KJ134379
  • GENBANK/KJ134380
  • GENBANK/KJ134381
  • GENBANK/KJ134382
  • GENBANK/KJ134383
  • GENBANK/KJ134384
  • GENBANK/KJ134385
  • GENBANK/KJ134386
  • GENBANK/KJ134387
  • GENBANK/KJ134388
  • GENBANK/KJ134389
  • GENBANK/KJ134390
  • GENBANK/KJ134391
  • GENBANK/KJ134392
  • GENBANK/KJ134393
  • GENBANK/KJ134394
  • GENBANK/KJ134395
  • GENBANK/KJ134396
  • GENBANK/KJ134397
  • GENBANK/KJ134398
  • GENBANK/KJ134399
  • GENBANK/KJ134400
  • GENBANK/KJ134401
  • GENBANK/KJ134402
  • GENBANK/KJ134403
  • GENBANK/KJ134404
  • GENBANK/KJ134405
  • GENBANK/KJ134406
  • GENBANK/KJ134407
  • GENBANK/KJ134408
  • GENBANK/KJ134409
  • GENBANK/KJ134410
  • GENBANK/KJ134411
  • GENBANK/KJ134412
  • GENBANK/KJ134413
  • GENBANK/KJ134414
  • GENBANK/KJ134415
  • GENBANK/KJ134416
  • GENBANK/KJ134417
  • GENBANK/KJ134418
  • GENBANK/KJ134419
  • GENBANK/KJ134420
  • GENBANK/KJ134421
  • GENBANK/KJ134422
  • GENBANK/KJ134423
  • GENBANK/KJ134424
  • GENBANK/KJ134425
  • GENBANK/KJ134426
  • GENBANK/KJ134427
  • GENBANK/KJ134428
  • GENBANK/KJ134429
  • GENBANK/KJ134430
  • GENBANK/KJ134431
  • GENBANK/KJ134432
  • GENBANK/KJ134433
  • GENBANK/KJ134434
  • GENBANK/KJ134435
  • GENBANK/KJ134436
  • GENBANK/KJ134437
  • GENBANK/KJ134438
  • GENBANK/KJ134439
  • GENBANK/KJ134440
  • GENBANK/KJ134441
  • GENBANK/KJ134442
  • GENBANK/KJ134443
  • GENBANK/KJ134444
  • GENBANK/KJ134445
  • GENBANK/KJ134446
  • GENBANK/KJ134447
  • GENBANK/KJ134448
  • GENBANK/KJ134449
  • GENBANK/KJ134450
  • GENBANK/KJ134451
  • GENBANK/KJ134452
  • GENBANK/KJ134453
  • GENBANK/KJ134454
  • GENBANK/KJ134455
  • GENBANK/KJ134456
  • GENBANK/KJ134457
  • GENBANK/KJ134458
  • GENBANK/KJ134459
  • GENBANK/KJ134460
  • GENBANK/KJ134461
  • GENBANK/KJ134462
  • GENBANK/KJ134463
  • GENBANK/KJ134464
  • GENBANK/KJ134465
  • GENBANK/KJ134466
  • GENBANK/KJ134467
  • GENBANK/KJ134468
  • GENBANK/KJ134469
  • GENBANK/KJ134470
  • GENBANK/KJ134471
  • GENBANK/KJ134472
  • GENBANK/KJ134473
  • GENBANK/KJ134474
  • GENBANK/KJ134475
  • GENBANK/KJ134476
  • GENBANK/KJ134477
  • GENBANK/KJ134478
  • GENBANK/KJ134479
  • GENBANK/KJ134480
  • GENBANK/KJ134481
  • GENBANK/KJ134482
  • GENBANK/KJ134483
  • GENBANK/KJ134484
  • GENBANK/KJ134485
  • GENBANK/KJ134486
  • GENBANK/KJ134487
  • GENBANK/KJ134488
  • GENBANK/KJ134489
  • GENBANK/KJ134490
  • GENBANK/KJ134491
  • GENBANK/KJ134492
  • GENBANK/KJ134493
  • GENBANK/KJ134494
  • GENBANK/KJ134495
  • GENBANK/KJ134496
  • GENBANK/KJ134497
  • GENBANK/KJ134498
  • GENBANK/KJ134499
  • GENBANK/KJ134500
  • GENBANK/KJ134501
  • GENBANK/KJ134502
  • GENBANK/KJ134503
  • GENBANK/KJ134504
  • GENBANK/KJ134505
  • GENBANK/KJ134506
  • GENBANK/KJ134507
  • GENBANK/KJ134508
  • GENBANK/KJ134509
  • GENBANK/KJ134510
  • GENBANK/KJ134511
  • GENBANK/KJ134512
  • GENBANK/KJ134513
  • GENBANK/KJ134514
  • GENBANK/KJ134515
  • GENBANK/KJ134516
  • GENBANK/KJ134517
  • GENBANK/KJ134518
  • GENBANK/KJ134519
  • GENBANK/KJ134520
  • GENBANK/KJ134521
  • GENBANK/KJ134522
  • GENBANK/KJ134523
  • GENBANK/KJ134524
  • GENBANK/KJ134525
  • GENBANK/KJ134526
  • GENBANK/KJ134527
  • GENBANK/KJ134528
  • GENBANK/KJ134529
  • GENBANK/KJ134530
  • GENBANK/KJ134531
  • GENBANK/KJ134532
  • GENBANK/KJ134533
  • GENBANK/KJ134534
  • GENBANK/KJ134535
  • GENBANK/KJ134536
  • GENBANK/KJ134537
  • GENBANK/KJ134538
  • GENBANK/KJ134539
  • GENBANK/KJ134540
  • GENBANK/KJ134541
  • GENBANK/KJ134542
  • GENBANK/KJ134543
  • GENBANK/KJ134544
  • GENBANK/KJ134545
  • GENBANK/KJ134546
  • GENBANK/KJ134547
  • GENBANK/KJ134548
  • GENBANK/KJ134549
  • GENBANK/KJ134550
  • GENBANK/KJ134551
  • GENBANK/KJ134552
  • GENBANK/KJ134553
  • GENBANK/KJ134554
  • GENBANK/KJ134555
  • GENBANK/KJ134556
  • GENBANK/KJ134557
  • GENBANK/KJ134558
  • GENBANK/KJ134559
  • GENBANK/KJ134560
  • GENBANK/KJ134561
  • GENBANK/KJ134562
  • GENBANK/KJ134563
  • GENBANK/KJ134564
  • GENBANK/KJ134565
  • GENBANK/KJ134566
  • GENBANK/KJ134567
  • GENBANK/KJ134568
  • GENBANK/KJ134569
  • GENBANK/KJ134570
  • GENBANK/KJ134571
  • GENBANK/KJ134572
  • GENBANK/KJ134573
  • GENBANK/KJ134574
  • GENBANK/KJ134575
  • GENBANK/KJ134576
  • GENBANK/KJ134577
  • GENBANK/KJ134578
  • GENBANK/KJ134579
  • GENBANK/KJ134580
  • GENBANK/KJ134581
  • GENBANK/KJ134582
  • GENBANK/KJ134583
  • GENBANK/KJ134584
  • GENBANK/KJ134585
  • GENBANK/KJ134586
  • GENBANK/KJ134587
  • GENBANK/KJ134588
  • GENBANK/KJ134589
  • GENBANK/KJ134590
  • GENBANK/KJ134591
  • GENBANK/KJ134592
  • GENBANK/KJ134593
  • GENBANK/KJ134594
  • GENBANK/KJ134595
  • GENBANK/KJ134596
  • GENBANK/KJ134597
  • GENBANK/KJ134598
  • GENBANK/KJ134599
  • GENBANK/KJ134600
  • GENBANK/KJ134601
  • GENBANK/KJ134602
  • GENBANK/KJ134603
  • GENBANK/KJ134604
  • GENBANK/KJ134605
  • GENBANK/KJ134606
  • GENBANK/KJ134607
  • GENBANK/KJ134608
  • GENBANK/KJ134609
  • GENBANK/KJ134610
  • GENBANK/KJ134611
  • GENBANK/KJ134612
  • GENBANK/KJ134613
  • GENBANK/KJ134614
  • GENBANK/KJ134615
  • GENBANK/KJ134616
  • GENBANK/KJ134617
  • GENBANK/KJ134618
  • GENBANK/KJ134619
  • GENBANK/KJ134620
  • GENBANK/KJ134621
  • GENBANK/KJ134622
  • GENBANK/KJ134623
  • GENBANK/KJ134624
  • GENBANK/KJ134625
  • GENBANK/KJ134626
  • GENBANK/KJ134627
  • GENBANK/KJ134628
  • GENBANK/KJ134629
  • GENBANK/KJ134630
  • GENBANK/KJ134631
  • GENBANK/KJ134632
  • GENBANK/KJ134633
  • GENBANK/KJ134634
  • GENBANK/KJ134635
  • GENBANK/KJ134636
  • GENBANK/KJ134637
  • GENBANK/KJ134638
  • GENBANK/KJ134639
  • GENBANK/KJ134640
  • GENBANK/KJ134641
  • GENBANK/KJ134642
  • GENBANK/KJ134643
  • GENBANK/KJ134644
  • GENBANK/KJ134645
  • GENBANK/KJ134646
  • GENBANK/KJ134647
  • GENBANK/KJ134648
  • GENBANK/KJ134649
  • GENBANK/KJ134650
  • GENBANK/KJ134651
  • GENBANK/KJ134652
  • GENBANK/KJ134653
  • GENBANK/KJ134654
  • GENBANK/KJ134655
  • GENBANK/KJ134656
  • GENBANK/KJ134657
  • GENBANK/KJ134658
  • GENBANK/KJ134659
  • GENBANK/KJ134660
  • GENBANK/KJ134661
  • GENBANK/KJ134662
  • GENBANK/KJ134663
  • GENBANK/KJ134664
  • GENBANK/KJ134665
  • GENBANK/KJ134666
  • GENBANK/KJ134667
  • GENBANK/KJ134668
  • GENBANK/KJ134860
  • GENBANK/KJ134861
  • GENBANK/KJ134862
  • GENBANK/KJ134863
  • GENBANK/KJ134864
  • GENBANK/KJ134865
  • GENBANK/KJ134866
  • GENBANK/KJ134867
  • GENBANK/KJ134868
  • GENBANK/KJ134869
  • GENBANK/KJ134870
  • GENBANK/KJ134871
  • GENBANK/KJ134872
  • GENBANK/KJ134873
  • GENBANK/KJ134874
  • GENBANK/KJ134875
  • GENBANK/KJ134876
  • GENBANK/KJ134877
  • GENBANK/KJ134878
  • GENBANK/KJ134879
  • GENBANK/KJ134880
  • GENBANK/KJ134881
  • GENBANK/KJ134882
  • GENBANK/KJ134883
  • GENBANK/KJ134884
  • GENBANK/KJ134885
  • GENBANK/KJ134886
  • GENBANK/KJ134887
  • GENBANK/KJ134888
  • GENBANK/KJ134889
  • PDB/4OCR
  • PDB/4OCS
  • PDB/4OCW
  • PDB/4OD1
  • PDB/4OD3
  • PDB/4ODH
  • PDB/4ORG
  • SRA/SRP017087
  • SRA/SRP034555