Selecting targets from eukaryotic parasites for structural genomics and drug discovery

Methods Mol Biol. 2014:1140:53-9. doi: 10.1007/978-1-4939-0354-2_4.

Abstract

The selection of targets is the first step for any structural genomics project. The application of structural genomics approaches to drug discovery also starts with the selection of targets. Here, three protocols are described that were developed to select targets from eukaryotic pathogens. These protocols could also be applied to other drug discovery projects.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Computational Biology
  • Drug Discovery / methods*
  • Eukaryota / genetics*
  • Genomics / methods
  • Humans
  • Molecular Biology / methods*
  • Parasites / genetics
  • Parasites / pathogenicity
  • Protein Conformation