Polyadenylation site prediction using PolyA-iEP method

Methods Mol Biol. 2014:1125:131-40. doi: 10.1007/978-1-62703-971-0_11.

Abstract

This chapter presents a method called PolyA-iEP that has been developed for the prediction of polyadenylation sites. More precisely, PolyA-iEP is a method that recognizes mRNA 3'ends which contain polyadenylation sites. It is a modular system which consists of two main components. The first exploits the advantages of emerging patterns and the second is a distance-based scoring method. The outputs of the two components are finally combined by a classifier. The final results reach very high scores of sensitivity and specificity.

MeSH terms

  • Computational Biology*
  • Poly A / metabolism*
  • Polyadenylation / physiology*
  • RNA, Messenger / chemistry
  • RNA, Messenger / genetics

Substances

  • RNA, Messenger
  • Poly A