Paclitaxel: new uses for an old drug

Drug Des Devel Ther. 2014 Feb 20;8:279-84. doi: 10.2147/DDDT.S56801. eCollection 2014.


Paclitaxel (Taxol), one of the most important anticancer drugs, has been used for therapy of different types of cancers. Mechanistically, paclitaxel arrests cell cycle and induces cell death by stabilizing microtubules and interfering with microtubule disassembly in cell division. Recently, it has been found that low-dose paclitaxel seems promising in treating non-cancer diseases, such as skin disorders, renal and hepatic fibrosis, inflammation, axon regeneration, limb salvage, and coronary artery restenosis. Future studies need to understand the mechanisms underlying these effects in order to design therapies with specificity.

Keywords: coronary artery restenosis; fibrosis; kidney; limb salvage; taxol inflammation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / therapeutic use*
  • Coronary Restenosis / drug therapy
  • Humans
  • Inflammation / drug therapy
  • Limb Salvage
  • Nerve Regeneration / drug effects
  • Paclitaxel / pharmacology
  • Paclitaxel / therapeutic use*
  • Pulmonary Fibrosis / drug therapy
  • Toll-Like Receptor 4 / physiology


  • Antineoplastic Agents, Phytogenic
  • Toll-Like Receptor 4
  • Paclitaxel