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Review
. 2014 Feb 20:6:235-43.
doi: 10.2147/IJWH.S37636. eCollection 2014.

Primary ovarian insufficiency: an update

Leticia Cox  1 , James H Liu  1
Affiliations
Review

Primary ovarian insufficiency: an update

Leticia Cox et al. Int J Womens Health. .

Abstract

Primary ovarian insufficiency is a condition that represents impaired ovarian function on a continuum with intermittent ovulation. This condition commonly leads to premature menopause, defined as cessation of ovulation prior to the age of 40 years. Because there are potential immediate and long-term consequences of hypoestrogenism, a timely diagnosis is invaluable. This comprehensive review will discuss identifiable causes for primary ovarian insufficiency, including genetic disorders and metabolic abnormalities, as well as review current strategies for diagnosis, evaluation, and management of women with this condition.

Keywords: ovarian dysfunction; premature menopause; premature ovarian failure.

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Figures

Figure 1
Figure 1
Laboratory testing to confirm diagnosis of primary ovarian insufficiency. Abbreviations: FSH, follicle-stimulating hormone; TSH, thyroid-stimulating hormone.
See this image and copyright information in PMC

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