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Review
. 2014;2014:436029.
doi: 10.1155/2014/436029. Epub 2014 Jan 30.

Regenerative Repair of Damaged Meniscus With Autologous Adipose Tissue-Derived Stem Cells

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Free PMC article
Review

Regenerative Repair of Damaged Meniscus With Autologous Adipose Tissue-Derived Stem Cells

Jaewoo Pak et al. Biomed Res Int. .
Free PMC article

Abstract

Mesenchymal stem cells (MSCs) are defined as pluripotent cells found in numerous human tissues, including bone marrow and adipose tissue. Such MSCs, isolated from bone marrow and adipose tissue, have been shown to differentiate into bone and cartilage, along with other types of tissues. Therefore, MSCs represent a promising new therapy in regenerative medicine. The initial treatment of meniscus tear of the knee is managed conservatively with nonsteroidal anti-inflammatory drugs and physical therapy. When such conservative treatment fails, an arthroscopic resection of the meniscus is necessary. However, the major drawback of the meniscectomy is an early onset of osteoarthritis. Therefore, an effective and noninvasive treatment for patients with continuous knee pain due to damaged meniscus has been sought. Here, we present a review, highlighting the possible regenerative mechanisms of damaged meniscus with MSCs (especially adipose tissue-derived stem cells (ASCs)), along with a case of successful repair of torn meniscus with significant reduction of knee pain by percutaneous injection of autologous ASCs into an adult human knee.

Figures

Figure 1
Figure 1
(a) Outcome of pain measurements. (b) Range of motion from the patient. VAS is visual analog scale and error bars indicate standard deviations (n = 3).
Figure 2
Figure 2
MRI sagittal sequential T2 views of the knee. Pretreatment MRI scans ((a) (sequential image: 5/20) and (c) (6/20)) show a tear (arrow) within the posterior horn of the medial meniscus. Posttreatment MRI scans at three months ((b) (5/20) and (d) (6/20)) indicate the healed meniscus (triangle) that has been repaired by ASCs mixture-based treatment.
Figure 3
Figure 3
MRI coronal sequential T2 views of the knee. Pretreatment MRI scans ((a) (sequential image: 14/20) and (c) (15/20)) show a tear (arrow) within the posterior horn of the medial meniscus. Posttreatment MRI scans at three months ((b) (14/20) and (d) (15/20)) indicate the healed meniscus (triangle) that has been restored by ASCs mixture-based treatment.

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References

    1. Englund M, Guermazi A, Gale D, et al. Incidental meniscal findings on knee MRI in middle-aged and elderly persons. The New England Journal of Medicine. 2008;359(11):1108–1115. - PMC - PubMed
    1. Magee T, Williams D. 3.0-T MRI of meniscal tears. American Journal of Roentgenology. 2006;187(2):371–375. - PubMed
    1. DeHaven KE. Decision-making factors in the treatment of meniscus lesions. Clinical Orthopaedics and Related Research. 1990;(252):49–54. - PubMed
    1. Newman AP, Daniels AU, Burks RT. Principles and decision making in meniscal surgery. Arthroscopy. 1993;9(1):33–51. - PubMed
    1. Jorgensen U, Sonne-Holm S, Lauridsen F, Rosenklint A. Long-term follow-up of meniscectomy in athletes. A prospective longitudinal study. Journal of Bone and Joint Surgery B. 1987;69(1):80–83. - PubMed

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