Effect of continuous light on spermatogenesis and testicular steroidogenesis in rats: possible involvement of alpha 2u-globulin

Nepal Med Coll J. 2013 Mar;15(1):62-4.


Male rats exposed to continous light for 70 days showed an increased weights of testis, accessory sex organs, serum levels of FSH, LH, testosterone, testicular 17beta-hydroxysteroid dehydrogenase (1beta-HSD) activity and alpha 2u-globulin, while 3beta-hydroxysteroid dehydrogenase activity showed no significant changes. Prolonged light exposure also stimulated sepermatogenesis in rats. These results suggest that alpha 2u-globulin possibly stimutates the male gonad by inducing pituitary gonadotropins in continuous light-exposed rats.

MeSH terms

  • 17-Hydroxysteroid Dehydrogenases / blood
  • Alpha-Globulins / metabolism*
  • Animals
  • Follicle Stimulating Hormone / blood
  • Light*
  • Luteinizing Hormone / blood
  • Male
  • Organ Size / radiation effects
  • Radioimmunoassay
  • Rats
  • Spermatogenesis / radiation effects*
  • Testis / radiation effects*
  • Testosterone / blood


  • Alpha-Globulins
  • alpha 2u globulin
  • Testosterone
  • Luteinizing Hormone
  • Follicle Stimulating Hormone
  • 17-Hydroxysteroid Dehydrogenases
  • 3 (or 17)-beta-hydroxysteroid dehydrogenase