Index pregnancy versus post-index pregnancy in patients with recurrent pregnancy loss

J Matern Fetal Neonatal Med. 2015 Jan;28(1):63-7. doi: 10.3109/14767058.2014.900752. Epub 2014 Apr 9.


Objective: To compare pregnancy outcomes of two consecutive pregnancies in a cohort of women with recurrent pregnancy loss (RPL), in order to determine the long-term prognosis of women with RPL managed in a dedicated RPL clinic.

Methods: A retrospective cohort study including 262 patients with two or more consecutive pregnancy losses followed by two subsequent pregnancies--index pregnancy (IP) and post-index pregnancy (PIP). All patients were evaluated and treated in the RPL clinic in the Soroka University Medical Center.

Results: Comparing IP with PIP, no significant difference in perinatal outcome was observed. The perinatal outcome remained encouraging with approximately 73% birth rate (73.7% versus 72.5%; p=0.83). Only 11% of the women with RPL continued to experience pregnancy losses for two subsequent pregnancies. In a multivariate logistic regression analysis, number of miscarriages pre-Index was the only factor independently associated with birth in the PIP.

Conclusion: There is no significant difference between IP and PIP regarding perinatal outcome. Appropriate management in the RPL clinic conferred a significant beneficial effect on long-term pregnancy outcome of a cohort of women with RPL.

Keywords: Birth rate; index pregnancy; long-term outcome; post-index pregnancy; pregnancy outcome; recurrent miscarriage; recurrent pregnancy loss.

Publication types

  • Comparative Study

MeSH terms

  • Abortion, Habitual / epidemiology*
  • Adult
  • Female
  • Humans
  • Israel / epidemiology
  • Live Birth / epidemiology*
  • Pregnancy
  • Retrospective Studies
  • Young Adult