Abstract
Four metabolites (1-4) of antroquinonol from rat urine, collected within 24 h after oral administration of antroquinonol, were characterized by HPLC-SPE-NMR. Compounds 1-4 were further isolated by semipreparative HPLC for structure confirmation. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic analyses and HRESIMS data.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Animals
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Antrodia / chemistry
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Chromatography, High Pressure Liquid / methods
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Male
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Rats
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Rats, Wistar
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Stereoisomerism
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Ubiquinone / analogs & derivatives*
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Ubiquinone / analysis
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Ubiquinone / pharmacology
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Ubiquinone / urine