Metabolites of antroquinonol found in rat urine following oral administration

J Nat Prod. 2014 Apr 25;77(4):1061-4. doi: 10.1021/np400670a. Epub 2014 Mar 4.

Abstract

Four metabolites (1-4) of antroquinonol from rat urine, collected within 24 h after oral administration of antroquinonol, were characterized by HPLC-SPE-NMR. Compounds 1-4 were further isolated by semipreparative HPLC for structure confirmation. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic analyses and HRESIMS data.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Antrodia / chemistry
  • Chromatography, High Pressure Liquid / methods
  • Male
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Rats
  • Rats, Wistar
  • Stereoisomerism
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / analysis
  • Ubiquinone / pharmacology
  • Ubiquinone / urine

Substances

  • Ubiquinone
  • antroquinonol