Labial soft tissue volume evaluation of different techniques for ridge preservation after tooth extraction: a randomized controlled clinical trial

J Clin Periodontol. 2014 Jun;41(6):612-7. doi: 10.1111/jcpe.12246. Epub 2014 Mar 26.


Objective: To volumetrically evaluate soft tissue changes of different ridge preservation techniques compared to spontaneous healing 6 months after tooth extraction.

Materials and methods: In each of 40 patients, one single-rooted tooth was extracted and four treatment modalities were randomly assigned to the following groups (n = 10 each): A) ß-tricalcium-phosphate-particles with a polylactid coating (ß-TCP), B) demineralized bovine bone mineral with 10% collagen covered with a collagen matrix (DBBM-C/CM), C) DBBM with 10% collagen covered with an autogenous soft tissue punch graft (DBBM-C/PG), D) spontaneous healing (control). Impressions were obtained before extraction and 6 months later, casts were digitized and volumetric changes at the buccal soft tissues were determined. One-way anova was performed and pair-wise Wilcoxon rank sum test with Bonferroni-Holm method was applied for comparison of differences between two groups.

Results: After 6 months, horizontal contour changes accounted for -1.7 ± 0.7 mm (A), -1.2 ± 0.5 mm (B), -1.2 ± 0.7 mm (C) and -1.8 ± 0.8 mm (D). None of the group comparisons reached statistical significance.

Conclusions: Six months after tooth extraction all groups revealed a horizontal volume change in the buccal soft tissue contour. Application of DBBM-C/CM or DBBM-C/PG reduced the amount of volume resorption compared to ß-TCP or spontaneous healing without reaching statistically significant difference.

Keywords: CAD/CAM; RCT; bone regeneration; bone substitute; graft material; human; ridge preservation.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alveolar Process / pathology
  • Alveolar Ridge Augmentation / methods*
  • Autografts / transplantation
  • Bone Substitutes / therapeutic use
  • Calcium Phosphates / therapeutic use
  • Collagen / therapeutic use
  • Cone-Beam Computed Tomography / methods
  • Follow-Up Studies
  • Gingiva / pathology*
  • Gingiva / transplantation
  • Guided Tissue Regeneration, Periodontal / methods
  • Humans
  • Image Processing, Computer-Assisted / methods
  • Imaging, Three-Dimensional / methods
  • Minerals / therapeutic use
  • Models, Dental
  • Polyesters / therapeutic use
  • Tooth Extraction / methods*
  • Tooth Socket / pathology
  • Wound Healing / physiology


  • Bio-Oss
  • Bone Substitutes
  • Calcium Phosphates
  • Minerals
  • Polyesters
  • beta-tricalcium phosphate-poly-L-lactide copolymer
  • Collagen