A direct copper-promoted three-component entry to trifluoromethylketoximes

Shuai Wang; Jing Nie; Yan Zheng; Jun-An Ma

doi:10.1021/ol500203m

A direct copper-promoted three-component entry to trifluoromethylketoximes

Org Lett. 2014 Mar 21;16(6):1606-9. doi: 10.1021/ol500203m. Epub 2014 Mar 5.

Authors

Shuai Wang¹, Jing Nie, Yan Zheng, Jun-An Ma

Affiliation

¹ Department of Chemistry, Key Laboratory of Systems Bioengineering (the Ministry of Education), Tianjin University, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , Tianjin 300072, P. R. of China.

PMID: 24597642
DOI: 10.1021/ol500203m

Abstract

A new copper-promoted three-component method for constructing ketoximes has been developed. This transformation can be achieved using indoles/pyrroles with the in situ generated 2,2,2-trifluorodiazoethane and nitrite species under mild conditions, thus offering a direct pathway to (E)-3-indolyl/2-pyrrolyl trifluoromethylketoximes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Copper / chemistry*
Hydrocarbons, Fluorinated / chemical synthesis*
Hydrocarbons, Fluorinated / chemistry
Indoles / chemical synthesis*
Indoles / chemistry
Molecular Structure
Oximes / chemical synthesis*
Oximes / chemistry
Stereoisomerism

Substances

Hydrocarbons, Fluorinated
Indoles
Oximes
Copper