Diet transiently improves migraine in two twin sisters: possible role of ketogenesis?

Funct Neurol. 2013 Oct-Dec;28(4):305-8. doi: 10.11138/FNeur/2013.28.4.305.


The ketogenic diet is a high-fat, low-carbohydrate diet long used to treat refractory epilepsy; ketogenesis (ketone body formation) is a physiological phenomenon also observed in patients following lowcarbohydrate, low-calorie diets prescribed for rapid weight loss. We report the case of a pair of twin sisters, whose high-frequency migraine improved during a ketogenic diet they followed in order to lose weight. The observed time-lock between ketogenesis and migraine improvement provides some insight into how ketones act to improve migraine.

Publication types

  • Case Reports

MeSH terms

  • Diet, Ketogenic*
  • Diseases in Twins / diet therapy*
  • Female
  • Humans
  • Middle Aged
  • Migraine Disorders / diet therapy*
  • Siblings