Chinese herbal medicines for treating osteoporosis
- PMID: 24599707
- PMCID: PMC10638660
- DOI: 10.1002/14651858.CD005467.pub2
Chinese herbal medicines for treating osteoporosis
Abstract
Background: Chinese herbal medicines have been used for a long time to treat osteoporosis. The evidence of their benefits and harms needs to be systematically reviewed.
Objectives: To assess the beneficial and harmful effects of Chinese herbal medicines as a general experimental intervention for treating primary osteoporosis by comparing herbal treatments with placebo, no intervention and conventional medicine.
Search methods: We searched the following electronic databases to January 2013: the Specialised Register of the Cochrane Complementary Medicine Field, CENTRAL, MEDLINE, EMBASE, LILACS, JICST-E, AMED, Chinese Biomedical Database and CINAHL.
Selection criteria: Randomised controlled trials of Chinese herbal medicines compared with placebo, no intervention or conventional medicine were included.
Data collection and analysis: Two authors extracted data and assessed risk of bias independently. Disagreement was resolved by discussion.
Main results: One hundred and eight randomised trials involving 10,655 participants were included. Ninety-nine different Chinese herbal medicines were tested and compared with placebo (three trials), no intervention (five trials) or conventional medicine (61 trials), or Chinese herbal medicines plus western medicine were compared with western medicine (47 trials). The risk of bias across all studies was unclear for most domains primarily due to inadequate reporting of study design. Although we rated the risk of selective reporting for all studies as unclear, only a few studies contributed numerical data to the key outcomes.Seven trials reported fracture incidence, but they were small in sample size, suffered from various biases and tested different Chinese herbal medicines. These trials compared Kanggusong capsules versus placebo, Kanggusong granule versus Caltrate or ipriflavone plus Caltrate, Yigu capsule plus calcium versus placebo plus calcium, Xianlinggubao capsule plus Caltrate versus placebo plus Caltrate, Bushen Zhuanggu granules plus Caltrate versus placebo granules plus Caltrate, Kanggusong soup plus Caltrate versus Caltrate, Zhuangguqiangjin tablets and Shujinbogu tablets plus calcitonin ampoule versus calcitonin ampoule. The results were inconsistent.One trial showed that Bushenhuoxue therapy plus calcium carbonate tablets and alfacalcidol had a better effect on quality of life score (scale 0 to 100, higher is better) than calcium carbonate tablets and alfacalcidol (mean difference (MD) 5.30; 95% confidence interval (CI) 3.67 to 6.93).Compared with placebo in three separate trials, Chinese herbal medicines (Migu decoction, Bushen Yigu soft extract, Kanggusong capsules) showed a statistically significant increase in bone mineral density (BMD) (e.g. Kanggusong capsules, MD 0.06 g/cm(3); 95% CI 0.02 to 0.10). Compared with no intervention in five trials, only two showed that Chinese herbal medicines had a statistically significant effect on increase in BMD (e.g. Shigu yin, MD 0.08 g/cm(3); 95% CI 0.03 to 0.13). Compared with conventional medicine in 61 trials, 23 showed that Chinese herbal medicines had a statistically significant effect on increase in BMD. In 48 trials evaluating Chinese herbal medicines plus western medication against western medication, 26 showed better effects of the combination therapy on increase in BMD.No trial reported death or serious adverse events of Chinese herbal medicines, while some trials reported minor adverse effects such as nausea, diarrhoea, etc.
Authors' conclusions: Current findings suggest that the beneficial effect of Chinese herbal medicines in improving BMD is still uncertain and more rigorous studies are warranted.
Conflict of interest statement
We certify that we have no affiliations with or involvement in any organisation or entity with a direct financial interest in the subject matter of the review (e.g. employment, consultancy, stock ownership, honoraria, expert testimony).
Figures
Update of
- doi: 10.1002/14651858.CD005467
Similar articles
-
Herbal medicines for viral myocarditis.Cochrane Database Syst Rev. 2013 Aug 28;(8):CD003711. doi: 10.1002/14651858.CD003711.pub5. Cochrane Database Syst Rev. 2013. Update in: Cochrane Database Syst Rev. 2016 May 03;(5):CD003711. doi: 10.1002/14651858.CD003711.pub6. PMID: 23986406 Updated. Review.
-
Herbal medicines for viral myocarditis.Cochrane Database Syst Rev. 2012 Nov 14;11:CD003711. doi: 10.1002/14651858.CD003711.pub4. Cochrane Database Syst Rev. 2012. Update in: Cochrane Database Syst Rev. 2013 Aug 28;(8):CD003711. doi: 10.1002/14651858.CD003711.pub5. PMID: 23152220 Updated. Review.
-
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.Cochrane Database Syst Rev. 2022 Feb 1;2(2022):CD014217. doi: 10.1002/14651858.CD014217. Cochrane Database Syst Rev. 2022. PMID: 36321557 Free PMC article.
-
Herbal medicines for fatty liver diseases.Cochrane Database Syst Rev. 2013 Aug 24;(8):CD009059. doi: 10.1002/14651858.CD009059.pub2. Cochrane Database Syst Rev. 2013. PMID: 23975682 Review.
-
Chinese herbal medicines for unexplained recurrent miscarriage.Cochrane Database Syst Rev. 2016 Jan 14;2016(1):CD010568. doi: 10.1002/14651858.CD010568.pub2. Cochrane Database Syst Rev. 2016. PMID: 26760986 Free PMC article. Review.
Cited by
-
Salvia miltiorrhiza in osteoporosis: a review of its phytochemistry, traditional clinical uses and preclinical studies (2014-2024).Front Pharmacol. 2024 Oct 3;15:1483431. doi: 10.3389/fphar.2024.1483431. eCollection 2024. Front Pharmacol. 2024. PMID: 39421672 Free PMC article. Review.
-
Additional effects of herbal medicine combined with bisphosphonates for primary osteoporosis: a systematic review and meta-analysis.Front Pharmacol. 2024 Sep 13;15:1413515. doi: 10.3389/fphar.2024.1413515. eCollection 2024. Front Pharmacol. 2024. PMID: 39346562 Free PMC article.
-
Osteoporosis treatment: current drugs and future developments.Front Pharmacol. 2024 Aug 12;15:1456796. doi: 10.3389/fphar.2024.1456796. eCollection 2024. Front Pharmacol. 2024. PMID: 39188952 Free PMC article. Review.
-
Comparative efficacy of acupuncture-related therapy for postmenopausal osteoporosis: protocol for Bayesian network meta-analysis.BMJ Open. 2023 Dec 30;13(12):e074740. doi: 10.1136/bmjopen-2023-074740. BMJ Open. 2023. PMID: 38159952 Free PMC article.
-
Network pharmacology-based mechanism prediction and pharmacological validation of Bushenhuoxue formula attenuating postmenopausal osteoporosis in ovariectomized mice.J Orthop Surg Res. 2023 Mar 14;18(1):200. doi: 10.1186/s13018-023-03696-7. J Orthop Surg Res. 2023. PMID: 36918900 Free PMC article.
References
References to studies included in this review
An SJ 2000 {published data only}
-
- An SJ, Li T, Li E. Effect of kidney‐tonifying herbs on ovary function and bone mass in postmenopausal women. Chinese Journal of Osteoporosis 2000;6(2):55‐9.
Cao GY 2010 {published data only}
-
- Cao GY, Zhang XM. Clinical observation of integrated traditional Chinese and western medicine in the treatment of osteoporosis. Nei Mongol Journal of Traditional Chinese Medicine 2010;29(2):18‐9.
Cao W 2010 {published data only}
-
- Cao W, Li JW. Clinical research of the treatment of postmenopausal osteoporosis with integration of traditional and western medicine. Journal of New Chinese Medicine 2010;42(4):44‐5.
Chen FS 2001 {published data only}
-
- Chen FS, Wei AS, Lang JM. Clinical observation on effect of 32 cases of postmenopausal osteoporosis treated with integrated traditional with western medicine. New Journal of Traditional Chinese Medicine 2001;33(11):42‐3.
Chen JP 1999 {published data only}
-
- Chen JP, Shao M, Du Y, Huang HX, Zhu BH, Lin YF. Clinical observation of the therapeutic effect of 36 cases with postmenopausal osteoporosis treated with Gukang oral solution. New Journal of Traditional Chinese Medicine 1999;31(7):22‐3.
Chen NQ 2006 {published data only}
-
- Chen NQ, An MH, Wu CL. Clinical study of Shenyao capsules on the treatment of 50 cases with primary osteoporosis. Clinical Journal of Traditional Chinese Medicine 2006;18(2):161‐2.
Chen X 2008 {published data only}
-
- Chen X. Curative effect observation of Gukangfang on treatment of primary osteoporosis. Zhejiang Journal of Integrative Traditional and Western Medicine 2008;18(7):402‐4.
Chen XL 2010 {published data only}
-
- Chen XL, Liang XH. Clinical observation of Heche Dazao pill on the treatment of 57 cases with primary osteoporosis. Guiding Journal of Traditional Chinese Medicine and Pharmacy 2010;16(8):40‐1.
Chen YQ 2001 {published data only}
-
- Chen YQ, Huang YH. Clinical study of a Chinese medicine of replenishing kidney in treating postmenopausal osteoporosis. China Contemporary Medicine 2001;7(4):57‐8.
Chen ZX 2002 {published data only}
-
- Chen ZX, Xu XJ, Huang G, Hu JM. Clinical study of the treatment of postmenopausal osteoporosis with Gushukang granule combined with calcium. Chinese Journal of Clinical Rehabilitation 2002;6(23):3541‐2.
Cui TH 1999 {published data only}
-
- Cui TH, Yu JH, Ding S, Wang RP, Liu H, Shi QY, et al. A clinical study in 74 cases of type primary osteoporosis treated with Chinese medicine Strong bone capsule. Suzhou University Journal of Medical Science 1999;19(12):1291‐4.
Dai Y 2007 {published data only}
-
- Dai Y, Shen L, Yang YP, Xie J, Zhou PQ. Effects of Migu tablet on bone mineral density, serum levels of osteoprotegerin and its ligand and bone metabolic markers in patients with postmenopausal osteoporosis. Chinese Journal of Integrative Traditional and Western Medicine 2007;27(8):696‐9. - PubMed
Deng WM 2012 {published data only}
-
- Deng WM, Zhang P, Huang H, Shen YG, Yang QH, Cui WL, et al. Five‐year follow‐up study of a kidney‐tonifying herbal Fufang for prevention of postmenopausal osteoporosis and fragility fractures. Journal of Bone and Mineral Metabolism 2012;30:517‐24. - PubMed
Dong Y 2010 {published data only}
-
- Dong Y, Lu Y, Hua LX. Efficacy of salmon calcitonin plus Xianlinggubao for osteoporosis and ostealgia in postmenopausal women: a clinical observation. China Pharmacy 2010;21(2):154‐6.
Dong YF 2004 {published data only}
-
- Dong YF. Clinical observation of Herba epimedii prescription in treating osteoporosis. Journal of Chinese Medicinal Materials 2004;27(8):620‐2.
Fan HX 2004 {published data only}
-
- Fan HX, Fan HY, Wang ZH. Clinical observation on the therapeutic effect of Gengnian Anyi tablet on postmenopausal osteoporosis. Tianjin Journal of Traditional Chinese Medicine 2004;21(1):20‐1.
Gang PH 2001 {published data only}
-
- Gang PH, Jiang SY. Clinical observation of Gumiling on osteoporosis. The national academic seminar of osteoporosis and osteoarthritis in 2001. 2001:327‐30.
Gong L 2001 {published data only}
-
- Gong L, Wang MY, Xia P, Cao JQ, Zhou JQ, Hu J. Clinical study of Yishen Zhuanggu mixture in treating 80 cases with primary osteoporosis. Chinese Journal of Osteoporosis 2001;7(2):149‐51.
Guo JH 2008 {published data only}
-
- Guo JH, Zhang YW, Zhao ZM, Yao RB, Shang W, Zang XL, et al. Effects of Bushen Kangsong pellet on bone mineral density in postmenopausal osteoporosis. Journal of Anhui Traditional Chinese Medicine College 2008;27(5):14‐5.
Han XL 2007 {published data only}
-
- Han XL, Lou ZJ, Shang FM, Lin HW. Clinical observation of Shugan zishen huoxue tang on 25 cases with postmenopausal osteoporosis. Liaoning Journal of Traditional Chinese Medicine 2007;34(9):1279‐80.
He MT 2007 {published data only}
-
- He MT, Liang XM, Liang ZJ, Zhang BD. Clinical study of Bushen Huoxue recipe on the treatment of postmenopausal osteoporosis. Shandong Journal of Traditional Chinese Medicine 2007;26(7):447‐9.
He N 2006 {published data only}
-
- He N. Treatment of postmenopausal osteoporosis by modified 'Zhaungyao Jianshen Tang': a therapeutic effect observation. Journal of Traditional Chinese Orthopedics and Traumatology 2006;18(11):10‐1.
He XQ 2006 {published data only}
-
- He XQ. Clinical study of Bushen Yangxue tang on the treatment of postmenopausal osteoporosis and effect on BMD. Journal of New Chinese Medicine 2006;38(4):42‐3.
Huang JW 2008 {published data only}
-
- Huang JW, Chen JC, Huang JH, Lin AJ, Lin XZ. The influence of bone mineral density and cell factors of Erxianyanggu decoction and alendronate sodium tablets for patients with osteoporosis. Journal of Traditional Chinese Orthopedics and Traumatology 2008;20(3):12‐3.
Huang ZJ 2008 {published data only}
-
- Huang ZJ, Chen JX, Bai YB. Clinical research of Zishengukang pill for osteoporosis. Letters in Biotechnology 2008;19(2):263‐4.
Hu J 2012 {published data only}
-
- Hu J, Li C. Clinical observation of Bushenjianpi treatment of primary osteoporosis. Hubei Journal of TCM 2012;34(4):11‐2.
Jian QQ 2010 {published data only}
-
- Jian QQ, Xu Y. Clinical observation on effect of integration of traditional and western medicine in treating postmenopausal osteoporosis. Journal of Sichuan of Traditional Chinese Medicine 2010;28(9):82‐3.
Lan ZX 2006 {published data only}
-
- Lan ZX, Li LZ, Zhang JT, Wang ZQ, Chen C, Liu JY. Clinical study of Guli on treating primary osteoporosis of deficiency in spleen and kidney. Journal of Sichuan Traditional Chinese Medicine 2006;24(6):75‐7.
Liang DB 2012 {published data only}
-
- Liang DB, Zhuang H. Clinical observation of Bushenhuoxue therapy of osteoporosis. Journal of New Chinese Medicine 2012;44(5):53‐5.
Liao L 2004 {published data only}
-
- Liao L, Li XS, Cai QH, Liang YS, Lai RB, Xiao WC, et al. Clinical research of the Bushen Shengsui principle treating postmenopausal osteoporosis. Chinese Journal of Information on traditional Chinese medicine 2004;11(4):287‐90.
Li BL 2007 {published data only}
-
- Li BL, Huang CB, Tan JW, Li YF, Yang B. The Influence of bone metabolism using traditional Chinese medicine Jianshenfang granule in treating of postmenopausal osteoporosis patients. Chinese Journal of Traditional Medical Traumatology & Orthopedics 2007;15(11):15‐7.
Li HW 2004 {published data only}
-
- Li HW, Liu F. Clinical observation on effect of Ziyin Bushen Zhuanggu prescription in treating postmenopausal osteoporosis. The Chinese Medicine Magazine of China 2004;2(3):114‐6.
Ling JY 2008 {published data only}
-
- Ling JY, Liu Q. Clinical study on treatment of postmenopausal osteoporosis by Bushenzhuanggu prescription. Chinese Journal of Traditional Medical Traumatology & Orthopedics 2008;16(4):22‐3.
Lin W 2000 {published data only}
-
- Lin W, Wu HF, Deng LP, Wei XY, Ye GC, Liu QS, et al. Clinical use of traditional Chinese medicine Migu decoction in treating postmenopausal osteoporosis. Chinese Journal of Osteoporosis 2000;6(3):71‐2.
Li SL 2004 {published data only}
-
- Li SL, Fan GJ, Tang AH, Liu CH, Luo GB, Tang XY. Clinical study of the treatment of postmenopausal osteoporosis with Strong bone capsule. Chinese Journal of Osteoporosis 2004;10(3):330‐2.
Liu JM 2012 {published data only}
-
- Liu JM, Xue L, Tian DX. Clinical research of primary osteoporosis treated with Gukang tablets. World Journal of Integrated Traditional and Western Medicine 2012;7(4):323‐5, 354.
Li YH 2008 {published data only}
-
- Li YH, Liu HH, Yang HJ, Li Y, Zhang LF, Liu F, et al. Clinical research of Jingujian granule for old people with osteoporosis. Beijing Journal of Traditional Chinese Medicine 2008;27(10):758‐61.
Li YH 2010 {published data only}
-
- Li YH, Xue L, Zhao FF, Zhu QQ, Li Y, Yang HJ. Effect of Jingujian granule on 129 primary osteoporosis cases. Journal of Traditional Chinese Medicine 2010;51(6):520‐3.
Li ZP 2011 {published data only}
-
- Li ZP, Tong HT, Sun GH, Lao RP, Liu ZJ. The effects of Kanggusong soup plus Caltrate on ALP and IL‐6 of postmenopausal osteoporosis. Journal of Yunnan University of Traditional Chinese Medicine 2011;34(4):37‐8, 46.
Li ZY 2006 {published data only}
-
- Li ZY, Liu BG, Liu YM, Zhang JX. Clinical observation of Xianling Gubao capsules on postmenopausal osteoporosis. Journal of Sichuan Traditional Chinese Medicine 2006;24(1):83‐4.
Lv ZH 2002 {published data only}
-
- Lv ZH, Wen ZJ, Wu SP, Qiu JM, Qiu JX. Clinical observation of Jianwei Bushen Zhuangjintang on the treatment of primary osteoporosis. China Journal of Orthopaedics and Traumatology 2002;15(5):263‐4.
Ma C 2011 {published data only}
-
- Ma C. Clinical analysis on Liuwei Dihuang pills plus calcium in treating postmenopausal osteoporosis. China Medicine and Pharmacy 2011;1(18):74‐5.
Ma CZ 2011 {published data only}
-
- Ma CZ. Clinical observation on combined treatment of traditional Chinese medicine and western medicine in treating osteoporosis. Journal of New Chinese Medicine 2011;43(9):56‐7.
Mao YF 2011 {published data only}
-
- Mao YF. Effect of Bushen Jianpi Jingu decoction on 75 postmenopausal osteoporosis. Beijing Journal of Traditional Chinese Medicine 2011;30(4):292‐3.
Ma YJ 2011 {published data only}
-
- Ma YJ, Ma YJ, Ma YL. A clinical observation on treating senile osteoporosis with Yishen Zhuanggu decoction. Chinese Journal of the Practical Chinese with Modern Medicine 2011;24(5):18‐9.
Meng XD 2003 {published data only}
-
- Meng XD, Xie YM, Huang YZ, Cui TH, Gao R, Tu RS, et al. Clinical study of Gujian capsule in treating primary osteoporosis with kidney‐yang deficiency syndrome. Chinese Journal of Clinical Rehabilitation 2003;7(3):445‐7, 457.
Miu JQ 2008 {published data only}
-
- Miu JQ. Clinical biochemical parameters observation of integrative Chinese and Western medicine for postmenopausal osteoporosis. Chinese Journal of Applied Physiology 2008;24(1):54‐5. - PubMed
Mu G 2001 {published data only}
-
- Mu G, Mu JJ, Wang P, Zhang K. Clinical observation of Bushen Qiangshen pill plus Caltrate on postmenopausal osteoporosis. Chinese Journal of Integrated Traditional with Western Medicine 2001;21(5):382‐3.
Mu G 2001a {published data only}
-
- Mu G, Wang P, Mu JJ. Clinical study of Bushen Qiangshen pill on postmenopausal osteoporosis. Chinese Journal of Traditional Medical Traumatology & Orthopedics 2001;9(1):20‐2.
Ou L 2011 {published data only}
-
- Ou L, Zeng XH, Zhao P. Clinical observation on Radix rehmanniae preparata and Radix astragali in treating postmenopausal osteoporosis. Beijing Journal of Traditional Chinese Medicine 2011;30(8):605‐6.
Peng T 2002 {published data only}
-
- Peng T, Huang ML, Xiong W, Wang L, Yang YP, Qi K, et al. Clinical and experimental study of Qianggu soft extract in treatment of type postmenopausal osteoporosis. Chinese Journal of Osteoporosis 2002;8(4):337‐41, 364.
Qiu RB 2004 {published data only}
-
- Qiu RB, Shen RZ, Zhang PQ. Treatment of postmenopausal osteoporosis with Yanghuo Sanzi tang‐‐‐A report of 30 cases. Journal of Traditional Chinese Medicine 2004;24(2):102‐4. - PubMed
Qiu RB 2008 {published data only}
-
- Qiu RB, Shen RZ, Zhang PQ, Chen YL, Ye HP, Zhang Y. Clinical study about treatment of postmenopausal osteoporosis with Jiangu recipe. Chinese Archives of Traditional Chinese Medicine 2008;26(7):1529‐30.
Qiu ZX 2010 {published data only}
-
- Qiu ZX. Observation of the effect of Xianlinggubao capsule on 67 senile osteoporosis. Chinese Journal of Traditional Medical Traumatology & Orthopedics 2010;18(8):52.
Qi ZX 1998 {published data only}
-
- Qi ZX, Lin HY. Clinical observation on Bushen Qianggutang in treating primary osteoporosis. Chinese Journal of Traditional Medical Traumatology & Orthopedics 1998;6(6):41‐2.
Ruan XY 2006 {published data only}
-
- Ruan XY, Qi JM, Liu YL, Ji Y, Chen BY. Effects of traditional Chinese medicine on bone mineral density and femoral neck strength in postmenopausal women. Chinese Journal of Osteoporosis 2006;12(2):181‐4.
Shao M 2003 {published data only}
-
- Shao M, Huang HX, Zhao J. Clinical observation on effect of Gukang oral preparation in treating postmenopausal osteoporosis. Journal of Traditional Chinese Orthopedics and Traumatology 2003;15(3):11‐2.
Shi CD 2012 {published data only}
-
- Shi CD, Yuan PW, Yang XH. Observation of Kangshu Jiangu granule on postmenopausal osteoporosis, a report of 40 cases. Shanxi Journal of Traditional Chinese Medicine 2012;28(1):16‐7.
Song XW 2000 {published data only}
-
- Song XW, Chen BX, Shen PZ. Clinical study on postmenopausal osteoporosis treated by kidney‐nourishing herbs. Shanghai Journal of Traditional Chinese Medicine 2000;34(7):28‐9.
Tang ZA 2012 {published data only}
-
- Tang ZA. Clinical observation on Bushen Qianggu Huoxue therapy in treating 42 primary osteoporosis. Guiding Journal of Traditional Chinese Medicine and Pharmacy 2012;18(4):50‐1.
Wang CC 2005 {published data only}
-
- Wang CC, Shang LL, Liang JY. Clinical observation on the therapeutic effect of Gumikang capsule plus nuclear honey beans on postmenopausal osteoporosis. Journal of Traditional Chinese Orthopedics and Traumatology 2005;17(8):15‐6.
Wang H 2007 {published data only}
-
- Wang H. Clinical observation of Qianggu paste II for old people with osteoporosis. Hubei Journal of Traditional Chinese Medicine 2007;29(10):54‐5.
Wang J 2007 {published data only}
-
- Wang J, Zhang WK, Wang ZH. Qianggu capsule for postmenopausal osteoporosis in 28 cases. Herald of Medicine 2007;26(11):1325‐7.
Wang JM 2008 {published data only}
-
- Wang JM, Liu T. Clinical observation of Gukang on bone quality in postmenopausal osteoporosis patients. Chinese Journal of Medical Traumatology & Orthopedics 2008;16(11):8‐9.
Wang SW 2003 {published data only}
-
- Wang SW, Zheng BR, Sun JY, Xie YH. Effects of Antai capsule on women with postmenopausal osteoporosis. Journal of the Fourth Military Medical University 2003;24(14):1324‐7.
Wang XD 2011 {published data only}
-
- Wang XD, Deng WM, Hong MJ, Liu F, Wang Q, Sun P. Clinical study on Hugu capsule in treating postmenopausal osteoporosis. Journal of Practical Medicine 2011;27(9):1662‐4.
Wang XY 2000 {published data only}
-
- Wang XY, Zhang CL, Mo LL, Qu YQ, Han LL. The effect of Bushen Jianpi herbs on bone metabolism and estrogen in perimenopausal woman. Journal of Guangzhou University of Traditional Chinese Medicine 2000;17(3):230‐2.
Wang YZ 2008 {published data only}
-
- Wang YZ, Wang HC. Clinical research of Jiangu capsule for osteoporosis. Chinese Journal of Guang Ming Chinese Medicine 2008;23(8):1125‐6.
Wang ZK 2004 {published data only}
-
- Wang ZK. The effects of Bushen Jianpi Migu prescription on pain and relevant biochemical indexes in patients with senile osteoporosis. Chinese Journal of Clinical Rehabilitation 2004;8(27):5930, 5949.
Wei RY 2011 {published data only}
-
- Wei RY, Lao RP, Liu ZJ, Xu GR, Li ZP. Effect of anti‐osteoporosis capsule on ostealgia and bone metabolism of postmenopausal osteoporosis patients. Journal of New Chinese Medicine 2011;43(1):61‐3.
Wu JZ 2010 {published data only}
-
- Wu JZ, Zhou XM, Zheng CX. Clinical observation of Erxian soup for primary osteoporosis. Journal of New Chinese Medicine 2010;42(2):25‐6.
Wu MS 2001 {published data only}
-
- Wu MS, Zhao SZ, Li E. Clinical study of Kanggusong granule in preventing and treating primary osteoporosis. Traditional Chinese Medicine Research 2001;14(1):26‐8. - PubMed
Wu MS 2007 {published data only}
-
- Wu MS, Li E, Zhao SZ, Bai X, Li AY. Channel tropism of the prescription for kidney tonifying by target‐oriented administration for osteoporosis. Journal of Clinical Rehabilitative Tissue Engineering Research 2007;11(27):5336‐40.
Wu W 2005 {published data only}
-
- Wu W, Li DF, Zhi XM, Han MQ. Preventive and therapeutic effects of Xianling Gubao capsule for postmenopausal osteoporosis. Journal of Guangzhou University of Traditional Chinese Medicine 2005;22(3):191‐3.
Xiao W 2008 {published data only}
-
- Xiao W, Huang MQ. Therapeutic effect observation of selfmade Gusong recipe for postmenopausal osteoporosis. Medicine Innovation Research 2008;5(14):67‐8.
Xie J 2004 {published data only}
-
- Xie J, Shen L, Yang YP, Zhou PQ, Gao L. Prevention action of Chinese herbs for tonifying kidney on bone loss in senile males: 1 year follow‐up. Chinese Journal of Clinical Rehabilitation 2004;8(24):5180‐1.
Xie YM 1997 {published data only}
-
- Xie YM, Zhang FZ, Zhou WQ, Gao P, Fu RJ, Zhao TY, et al. Clinical study of Bugu Shengsui capsule in treating primary osteoporosis with kidney‐yang deficiency syndrome. Chinese Journal of Integrated Traditional and Western Medicine 1997;17(9):526‐30. - PubMed
Xiong YH 2008 {published data only}
-
- Xiong YH, Teng WR, Liu T, Fu SC, Gu PF, Fu WY, et al. Jiangu granules in treatment of postmenopausal osteoporosis: a randomized, double‐blind, double dummy, multicenter clinical trial. Chinese Journal of Traditional Medical Traumatology & Orthopedics 2008;16(4):17‐21.
Xu H 2010 {published data only}
-
- Xu H, Ren DH, Liang Z, Wang J. Clinical observation of Qianggu capsule plus alendronate on postmenopausal osteoporosis. Journal of Zhejiang University of Traditional Chinese Medicine 2010;34(4):503‐4.
Xu M 2009 {published data only}
-
- Xu M, Liu BX, Huang CJ, Tang FY, Lou YM, Liang Z, et al. Clinical observation of Xianlinggubao plus alendronate on postmenopausal osteoporosis. Journal of Liaoning University of Traditional Chinese Medicine 2009;11(1):94‐5.
Xu W 2005 {published data only}
-
- Xu W, Chen YC, Zhang JF. Clinical observation on effect of Yishen Yanggan mixture in treating liver‐kidney deficiency postmenopausal osteoporosis. Chinese Traditional and Herbal Drugs 2005;36(6):898‐9.
Xu YL 2007 {published data only}
-
- Xu YL, Jin JJ, Xu DY, Zheng Y. Effects of acupoint sticking of Migudan on bone Gla protein and hydroxyproline in the patients of primary osteoporosis. Chinese Journal of Information on Traditional Chinese Medicine 2007;14(6):17‐9.
Yang B 2007 {published data only}
-
- Yang B, Yang J. Clinical research of Huangqi for patients with postmenopausal osteoporosis. Sichuan Medical Journal 2007;28(3):291‐3.
Ye AN 1998 {published data only}
-
- Ye AN. Clinical observation of Bushen Zhuanggutang in treating 60 cases with senile osteoporosis. New Journal of Traditional Chinese Medicine 1998;30(7):52‐3.
Yuan YN 2000 {published data only}
-
- Yuan YN, Liu Y, Han P. Treatment of 30 cases of primary osteoporosis with Shanke Jiegu tables. Hunan Guiding Journal of Traditional Chinese Medicine and Pharmacology 2000;6(9):31‐2.
Zhang DS 2011 {published data only}
-
- Zhang DS, Cao W, Chen H, Zhang FK. Treatment of integration of traditional and western medicine on 60 cases with postmenopausal osteoporosis. Traditional Chinese Medicinal Research 2011;24(3):34‐6.
Zhang J 2003 {published data only}
-
- Zhang J, Yin SL, Yin HQ, Ling HW, Li W, Li XQ. Clinical observation on effect of Liuwei Dihuang pills in treating postmenopausal osteoporosis. Journal of Clinical Internal Medicine 2003;20(10):558.
Zhang RH 2004 {published data only}
-
- Zhang RH, Chen KJ, Lu DX, Zhu XF, Ma XC. Clinical study on treatment of postmenopausal osteoporosis by Yiigu capsule. Chinese Journal of Integrated Traditional with Western Medicine 2004;24(8):680‐4. - PubMed
Zhang XG 2011 {published data only}
-
- Zhang XG. Effect of Zhuangguyin on 100 cases with primary osteoporosis. Acta Chinese Medicine and Pharmacology 2011;39(1):109‐11.
Zhang XJ 2008 {published data only}
-
- Zhang XJ, He BR, Nie J. Clinical study on effect of Bushenhuoxue capsules for treatment of osteoporosis in aged males. Chinese Archives of Traditional Chinese Medicine 2008;26(2):307‐11.
Zhang XZ 2004 {published data only}
-
- Zhang XZ, Han JF, Qian GF, He M, Li Y, Gu L. Effects of Xianlinggubao capsule on bone mineral density and cytokines in postmenopausal osteoporotic patients. Chinese Journal of Osteoporosis 2004;10(1):90‐3.
Zhang YL 1996 {published data only}
-
- Zhang YL, Wu SL. Clinical observation of herbal medicine in treating 120 senile male cases with primary osteoporosis. New Journal of Traditional Chinese Medicine 1996;28(2):58‐60.
Zhang YP 2007 {published data only}
-
- Zhang YP, Cui YH, Kang HY, Zhang B. Therapeutic effect observation and influence of bone formation and damage indexes of Shigu yin for patients with postmenopausal osteoporosis. Journal of New Chinese Medicine 2007;39(1):30‐1.
Zhang YS 2003 {published data only}
-
- Zhang YS, Zhai MY, Guo L, Liu N, Han MX, Bai XM. Clinical and experimental study of the treatment of primary osteoporosis with Huoluo Gukang pills. Journal of Traditional Chinese Orthopedics and Traumatology 2003;15(7):9‐11.
Zhang ZF 2011 {published data only}
-
- Zhang ZF, Ye WH. Effect of Zhuangguqiangjin tablet on cases with liver and kidney deficiency osteoporosis. Journal of New Chinese Medicine 2011;43(5):70‐2.
Zhan HS 2009 {published data only}
-
- Zhan HS, Shi YY, Zhao YF, Hu XY, He ZY, Lou XF, et al. Phase clinical investigation of Xuduanzhuanggu capsules to the primary osteoporotic patient. Chinese Journal of Osteoporosis 2009;15(3):197‐200.
Zhan ML 2007 {published data only}
-
- Zhan ML, Yang YF, Zhang J, Li JP. Therapeutic effect observation of Bushenyangxue decoction for postmenopausal osteoporosis. Gansu Journal of Traditional Chinese Medicine 2007;20(2):37‐8.
Zhao G 2002 {published data only}
-
- Zhao G, Cai DF, Dong SF, Fan Y. Clinical study in 25 cases of postmenopausal osteoporosis treated with Zishen prescription. Journal of Traditional Chinese Medicine 2002;43(6):444‐5. - PubMed
Zhao HX 2001 {published data only}
-
- Zhao HX. Clinical efficacy of Kanggusong capsule in treating postmenopausal osteoporosis. Chinese Journal of Traditional Chinese Medicine and Pharmacy 2001;16(2):31‐3.
Zhao LN 2003 {published data only}
-
- Zhao LN. Preventive and therapeutic effects of Yinyanghuo for osteoporosis. Modern Journal of Integrated Traditional Chinese and Western Medicine 2003;12(9):922‐3.
Zheng WK 2007 {published data only}
-
- Zheng WK, Liu CY, Han CY, Zhou YJ. Clinical study on treatment of postmenopausal osteoporosis by Jinwugutong capsule. Chinese Journal of Traditional Medical Traumatology & Orthopedics 2007;15(3):30‐2.
Zhong RQ 2007 {published data only}
-
- Zhong RQ, Pan GM, Deng WM, Zhang GC. Clinical study of Gushenyijingtang on the treatment of primary osteoporosis of deficiency in kidney yang. Chinese Journal of Traditional Medical Traumatology & Orthopedics 2007;15(9):16‐8.
Zhou LZ 2001 {published data only}
-
- Zhou LZ, Ma Y. Clinical observation of traditional Chinese medicine on primary osteoporosis. The National Academic Seminar of Osteoporosis and Osteoarthritis in 2001. 2001:134‐9.
Zhou XT 2001 {published data only}
-
- Zhou XT. Clinical research of 45 cases with osteoporosis treated by Guilu Erxiantang. Jiangsu Journal of Traditional Chinese Medicine 2001;22(6):28.
Zhou ZK 2006 {published data only}
-
- Zhou ZK, Zeng HB, Qin JJ, Chen C. Clinical observation of Huangqi Sanxian tang on 30 cases with postmenopausal osteoporosis. Journal of New Chinese Medicine 2006;38(6):40‐1.
Zhu HJ 2011 {published data only}
-
- Zhu HJ, Duan ZZ, Liao KH, Tan N, Huang SG. Clinical observation on Bushen Tianjing Huoxue therapy in treating primary osteoporosis. Guiding Journal of Traditional Chinese Medicine and Pharmacy 2011;17(12):30‐2.
Zhu HM 2012 {published data only}
-
- Zhu HM, Qin L, Garnero P, Genant HK, Zhang G, Dai K, et al. The first multicenter and randomized clinical trial of herbal Fufang for treatment of postmenopausal osteoporosis. Osteoporosis International 2012;23:1317‐27. - PubMed
Zou JJ 2005 {published data only}
-
- Zou JJ, Liu ZM, Zheng JY, Zhao WM, Liu Y, Shi YQ. Clinical investigation of Gu Ben Jian Gu capsules to the primary osteoporotic patient. Journal of Practical Training of Medicine 2005;33(2):96‐8.
References to studies excluded from this review
Ai SC 2003 {published data only}
-
- Ai SC, Yang L, Liao FZ, Chen XL. Influence of herbal application at Shenque (CV 8) on BGP in primary osteoporosis. Shanghai Journal of Acupuncture and Moxibustion 2003;22(3):39‐40.
Ai SC 2003a {published data only}
-
- Ai SC, Wong M, Liao FZ, Chen XL. Influence of herbal application at Shenque on interleukin‐6 in primary osteoporosis. Journal of Sichuan of Traditional Chinese Medicine 2003;21(2):13‐5.
Bo LY 2003 {published data only}
-
- Bo LY, Wu CS, Wang XX. Clinical observation on the use of Gushukang in treating of osteoporotic compression fracture of the spine. Chinese Journal of Bone Tumor and Bone Disease 2003;2(5):298‐300.
Chen AP 2005 {published data only}
-
- Chen AP, Chen YZ. Clinical observation on effect of Liuwei Dihuang pills in treating senile osteoporosis. Journal of Chinese Modern Medicine 2005;2(5):456‐7.
Chen JJ 2010 {published data only}
-
- Chen JJ, Lou Q, Ning JC. Analysis of CT bone mineral density of senile osteoporosis cases treated by integration of traditional Chinese and western medicine. International Medicine & Health Guidance News 2010;16(12):1488‐90.
Chen XF 2003 {published data only}
-
- Chen XF, Jiang YX. Effect of Xianling Gubao plus vitamin D3 and calcium amino acid chelate on bone mineral density and pain in osteoporosis. Chinese Journal of Clinical Rehabilitation 2003;7(27):3769.
Chen XF 2007 {published data only}
-
- Chen XF, Lan TF. Therapeutic effect observation of Bushen Jianpi Huoxue method for patients with senile osteoporosis. Journal of Sichuan of Traditional Chinese Medicine 2007;25(10):60‐1.
Dai Y 2007a {published data only}
-
- Dai Y, Shen L. Effects of Migu tablet on bone mineral density, serum matrix metalloproteinase‐2 level and bone metabolic markers in postmenopausal osteoporosis. China Journal of Chinese Materia Medica 2007;32(22):2409‐12. - PubMed
Deng WM 1997 {published data only}
-
- Deng WM, He YS, Feng YJ. Clinical study on postmenopausal osteoporosis syndrome treated with tonifying kidney to strength bone decoction. Chinese Journal of Traditional Medical Science and Technology 1997;4(2):70‐2.
Deng WM 1997a {published data only}
-
- Deng WM, He YS, Feng YJ. Clinical effect of kidney‐tonifying herbs on postmenopausal osteoporosis. Chinese Journal of Osteoporosis 1997;3(1):64‐6.
Deng WM 2001 {published data only}
-
- Deng WM, Shen YG, He YS, Wei S. Influences of Bushen Zhuanggu granule on contents of sexual hormones and metabolism of calcium and phosphorous in early menopausal woman. Journal of Guangzhou University of Traditional Chinese Medicine 2001;18(4):301‐3.
Deng WM 2002 {published data only}
-
- Deng WM, Cui WL, Shen YG, Yang QH, He YS, Wei S. Effects of a 2‐year treatment with Bushen Zhuanggu granule for postmenopausal osteoporosis. Journal of Guangzhou University of Traditional Chinese Medicine 2002;19(4):275‐8.
Ding GZ 1995 {published data only}
-
- Ding GZ, Zhang ZL, Zhou Y, Li R. Clinical study on effect of Bushen Jiangu capsule on postmenopausal osteoporosis. Chinese Journal of Integrated Traditional and Western Medicine 1995;15(7):392‐4. - PubMed
Dong YL 2004 {published data only}
-
- Dong YL. Clinical observation of Liuwei Dihuang pills combined with west medicine in treating 60 senile patients with deficiency of kidney‐YIN osteoporosis. Clinical Journal of Traditional Chinese Medicine 2004;16(2):135‐6.
Fan GF 2008 {published data only}
-
- Fan GF, Qi ZJ, Chen RX, Dong SL, Wang FG, Zhou CJ. Therapeutic effect observation of Qiangjin Zhuanggu pill for patients with primary osteoporotic lumbago and backache. Journal of Traditional Chinese Orthopedics and Traumatology 2008;20(2):13‐4.
Fan ZY 1995 {published data only}
-
- Fan ZY. Clinical observation on effect of Yugu pill in treating osteoporosis. Journal of Sichuan of Traditional Chinese Medicine 1995;13(1):43‐4.
Ge L 2005 {published data only}
-
- Ge L, Dai FF, Cai X. Clinical observation of treating primary osteoporosis of female patients with Jiangu pills. Jiangsu Journal of Traditional Chinese Medicine 2005;26(3):24‐5.
Gong L 2000 {published data only}
-
- Gong L, Wang MY, Cao JQ, Xu F, Zhou PQ, Hu J. Clinical study of Yishen Zhuanggu mixture in treating 17 cases with osteoporosis. Journal of Traditional Chinese Medicine 2000;41(10):606‐7.
Gong ZF 2011 {published data only}
-
- Gong ZF. Effect of Bushenshujing soup and Celecoxib on primary osteoporosis with low back pain. Chinese Journal of Clinical Research 2011;24(2):155‐6.
Gu M 2004 {published data only}
-
- Gu M, Guo JN. Clinical study of the treatment of primary osteoporosis with Fortune's drynaria rhizome. Chinese Journal of Rehabilitation 2004;19(5):297.
Guo F 2003 {published data only}
-
- Guo F. Clinical observation on Yishen Yanggan decoction treating 30 cases of osteoporosis. Modern Diagnosis & Treatment 2003;14(5):268‐9.
Guo HN 1998 {published data only}
-
- Guo HN, Wang WZ, Tian WM. Clinical observation of herbal medicine in treating 120 primary osteoporosis. Journal of Hebei Traditional Chinese Medicine and Pharmacology 1998;13(3):4‐6.
Gu T 2011 {published data only}
-
- Gu T, Jin W. Integration of traditional and western medicine on 26 primary osteoporosis. Yunnan Journal of Traditional Chinese Medicine and Materia Medica 2011;32(4):32.
He YC 2008 {published data only}
-
- He YC, Liao KX, Huang YR, Jiang TB. Curative effect of Xianlinggubao capsule on thoracolumbar burst fracture in senile patients with osteoporosis. Chinese Journal of Traditional Medical Traumatology & Orthopedics 2008;163(312‐13):12‐3.
Hu XD 2011 {published data only}
-
- Hu XD. Clinical discussion on treating 164 cases of patients with senile osteoporosis in TCM. Clinical Journal of Chinese Medicine 2011;3(3):94‐5.
Jia JH 2010 {published data only}
-
- Jia JH, Chen XF, Zhang Z, Wang XP. Shugukang decoction in the treatment of primary osteoporosis: a clinical observation of 60 cases. Journal of Anhui Traditional Chinese Medical College 2010;29(1):28‐31.
Jiang SY 1995 {published data only}
-
- Jiang SY, Shang YP, Wu LS, Liu BY, Zhang L, Guo RY, et al. Clinical observation of Gushukang granule on osteoporosis. Chinese Journal of Osteoporosis 1995;1(2):158, 167‐9.
Ke Q 2005 {published data only}
-
- Ke Q, Liu HQ, Niu W. Effect of kidney‐tonifying herbs on bone mineral density, serum calcium and serum alkaline phosphatase in postmenopausal osteoporosis patients. Chinese Journal of Clinical Rehabilitation 2005;9(31):186, 189.
Ke Q 2005a {published data only}
-
- Ke Q, Liu HQ, Chen XC, Wu DF. Clinical observation of kidney‐tonifying herbs in treating 95 senile male cases with renal deficiency primary osteoporosis. Information on Traditional Chinese Medicine 2005;22(6):26‐7.
Li BL 2007a {published data only}
-
- Li BL, Li YF, Tan JW, Geng WZ, Zhan Q. Effect of bone metabolism index of Jianshen prescription for patients with postmenopausal osteoporotic vertebral fracture. Journal of Traditional Chinese Orthopedics and Traumatology 2007;19(9):4‐5.
Li CX 2005 {published data only}
-
- Li CX. Effect of movement therapy plus herbal medicine on bone mineral density in senile osteoporosis. Chinese Journal of Clinical Rehabilitation 2005;9(7):95, 97.
Li JF 2008 {published data only}
-
- Li JF, Xiao YH. Therapeutic effect observation of Bushen Qianggu tang for primary osteoporosis. Practical Clinical Medicine 2008;9(5):66‐7.
Lin HY 1998 {published data only}
-
- Lin HY, Qi ZX. Clinical observation of Yishen Jiangu tang in treating osteoporosis. Fujian Journal of Traditional Chinese Medicine 1998;29(2):9‐10.
Liu HB 2005 {published data only}
-
- Liu HB, Ai SC, Wu LD. Clinical observation of medicine‐separated sticking on Shenque on sex hormone in primary osteoporosis. Journal of Sichuan of Traditional Chinese Medicine 2005;23(9):74‐5.
Liu HQ 2010 {published data only}
-
- Liu HQ, Qin JJ. Effect of Gukang granule in treating postmenopausal osteoporosis with kidney yang deficiency. Journal of Shandong University of TCM 2010;34(1):48‐9.
Liu TS 2008 {published data only}
-
- Liu TS. Therapeutic effect of integrative Chinese and Western medicine for patients with osteoporosis in 62 cases. Journal of Shanxi College of Traditional Chinese Medicine 2008;9(6):34‐5.
Liu YS 2011 {published data only}
-
- Liu YS. Treatment of 49 cases of postmenopausal osteoporosis with Jiaweierxian soup. Guangming Journal of Chinese Medicine 2011;26(4):698‐9.
Liu YX 1998 {published data only}
-
- Liu YX. Clinical study of Fuguning granule on postmenopausal osteoporosis. Liaoning Journal of Traditional Chinese Medicine 1998;25(6):284‐5.
Li YM 2005 {published data only}
-
- Li YM. Treatment of 60 cases of postmenopausal osteoporosis with Bushen Huoxue preparation. Journal of Nanjing University of Traditional Chinese Medicine 2005;21(1):56‐7.
Luo QY 2011 {published data only}
-
- Luo QY, Wen DH. Treatment of 24 cases of senile osteoporosis with Huoluoxiaoling pill. Journal of Practical Traditional Chinese Medicine 2011;27(4):245.
Lu W 2004 {published data only}
-
- Lu W, Chu XG, Peng TP. Clinical study of the treatment of primary osteoporosis with Bushen Jiangu tang. Jiangxi Journal of Traditional Chinese Medicine 2004;35(259):27.
Lu ZD 2004 {published data only}
-
- Lu ZD, Wang YS. Clinical observation of Gushukang in treating 80 primary osteoporosis patients. Chinese Journal of Clinical Rehabilitation 2004;8(18):3652.
Pan X 2004 {published data only}
-
- Pan X, Wang DY. Treatment of 34 cases of primary osteoporosis with Huangqi injection to acupoint. Shanxi Journal of Traditional Chinese Medicine 2004;25(12):1133‐4.
Peng T 2003 {published data only}
-
- Peng T, Chu ZR, Lu Y, Qi K, Liu JQ, Huang JH. Clinical observation of Qianggu extracts in treating postmenopausal osteoporosis. Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai 2003;17(3):25‐7.
Qi ZX 2000 {published data only}
-
- Qi ZX, Lin HY. The clinical research of Shengsuiyin on the primary osteoporosis. Chinese Journal of Traditional Medical Traumatology & Orthopedics 2000;8(5):21‐2.
Ren JH 2011 {published data only}
-
- Ren JH. Effect of Jinwugutong and alendronate sodium on postmenopausal osteoporosis patients with pain. Guiding Journal of Traditional Chinese Medicine and Pharmacy 2011;17(1):60‐1.
Shang YM 2007 {published data only}
-
- Shang YM, Liu YY, Li HP. Clinical observation of Xianlinggubao capsule on postmenopausal osteoporosis. Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care 2007;14(1):55.
Shi B 2010 {published data only}
-
- Shi B. Clinical observation of traditional Chinese Medicine for senile osteoporosis. Chinese Journal of Ethnomedicine and Ethnopharmacy 2010;19(12):39‐40.
Shou ZX 2008 {published data only}
-
- Shou ZX, Shen L, Fan H, Xie J, Yang YP, Zhou PQ, et al. Clinical observation on Qianggu Huoli pills in the treatment of primary osteoporosis. Chinese Journal of Traditional Medical Traumatology & Orthopedics 2008;16(10):1‐2.
Shuai B 2008 {published data only}
-
- Shuai B, Shen L, Yang YP, Xie J, Zhou PQ, Gao L, et al. Clinical study (phase III) on the effects of Jiangu granula in primary osteoporosis. Chinese Journal of Traditional Medical Traumatology & Orthopedics 2008;16(3):27‐30.
Shu J 2005 {published data only}
-
- Shu J. Clinical observation of Bushen Yijing prescription in treating 50 osteoporosis patients. Journal of Occupational Health and Damage 2005;20(2):143‐4.
Song HX 2003 {published data only}
-
- Song HX. Treatment of 84 cases of osteoporosis with Bushen Yijing method. Shanxi Journal of Traditional Chinese Medicine 2003;24(12):1075‐7.
Song XW 1997 {published data only}
-
- Song XW, Song ZJ, Shen PZ. Clinical observation of Bushen herbal medicine in treating postmenopausal osteoporosis. The Practical Journal of Integrating Chinese with Modern Medicine 1997;10(9):892.
Song XW 2001 {published data only}
-
- Song XW, Shen PZ, Chen BX. Clinical study of Bushenhuoxue recipe on postmenopausal osteoporosis. China Journal of Orthopaedics and Traumatology 2001;14(8):476.
Su CH 2004 {published data only}
-
- Su CH, Cui TH, Sang SB, Wu YW, Ding S, Jiang YM, et al. Comparison of strong bone capsule and calcium carbonate combined with vitamin D in the treatment of senile osteoporosis. Chinese Journal of Clinical Rehabilitation 2004;8(29):6429‐31.
Su CH 2005 {published data only}
-
- Su CH, Cui TH, Sang SB, Wu YW, Wang DL, Jiang JW, et al. Clinical study of 105 patients with postmenopausal osteoporosis treated by TCM strong bone capsule and Caltrate. Liaoning Journal of Traditional Chinese Medicine 2005;32(7):701‐3.
Sun JM 2002 {published data only}
-
- Sun JM, Fu GM, Zhang HL. Analysis of the therapeutic effect of Yiqi Tiansui mixture on osteoporosis. Chinese Journal of Clinical Rehabilitation 2002;6(9):1309.
Sun X 2002 {published data only}
-
- Sun X. Clinical observation of the therapeutic effect of Jiawei Zuogui pill on osteoporosis with back pain. Chinese Journal of Traditional Medical Traumatology & Orthopedics 2002;10(5):36‐7.
Sun YM 2008 {published data only}
-
- Sun YM, Wang PM, Zha W, Zhao HQ, Xia JL, Liu XQ, et al. Research on the influence of the manifestations in the primary osteoporosis patients by Ge Gen (Radix Puerariae). Chinese Journal of Traditional Medical Traumatology & Orthopedics 2008;16(4):14‐6.
Su YB 2008 {published data only}
-
- Su YB, Li MX, Lin YF, Zheng YM, Wu ZB, Rao HC, et al. Clinical observation of Qianggu Huoxue tang for primary osteoporosis combined with distal radius fracture. Journal of Traditional Chinese Orthopedics and Traumatology 2008;20(7):17‐8.
Su ZW 2010 {published data only}
-
- Su ZW, Zheng ZY, Jin J. Clinical observation of Bushenzhuanggu soup for primary osteoporosis. Journal of Hebei Traditional Chinese Medicine and Pharmacology 2010;25(1):17‐8.
Tang JM 1999 {published data only}
-
- Tang JM, Liu KJ, Wang GX. Effect of Jiangu powder on bone mineral density in three type of renal deficiency of osteoporosis. Chinese Journal of Information on Traditional Chinese Medicine 1999;6(10):51.
Tan X 2010 {published data only}
-
- Tan X, Huang H, Liu Z, Liu HY, Shao Y, Ceng D, et al. Clinical study of the effect of Bushen Zhuanggu powder on bone transformation in aged males with osteoporosis. Chinese Journal of Traditional Medical Traumatology & Orthopedics 2010;18(7):17‐20.
Tu PS 2008 {published data only}
-
- Tu PS, Deng WQ, Li MJ, Wu XY, Lv ZY, Zhou HJ. Clinical observation of Shuanggu decoction for patients with postmenopausal osteoporosis in 30 cases. Chinese Journal of Traditional Medical Science and Technology 2008;15(6):471‐2.
Wang CH 2003 {published data only}
-
- Wang CH, Tian LM, Jiang YP, Li JC, Chen XF, Li F, et al. Clinical effects of Gusongkang capsule on senile osteoporosis. Journal of the Fourth Military Medical University 2003;24(11):1029‐31.
Wang GH 2011 {published data only}
-
- Wang GH, Wei XX. Clinical observation on primary osteoporosis treated by Zhuanggutongluobao. China Journal of Chinese Medicine 2011;26(8):999‐1000.
Wang HM 1998 {published data only}
-
- Wang HM, Ge JR, Li N. Clinical observation of treating osteoporosis of old people with Bugu capsule. Chinese Journal of Traditional Medical Traumatology & Orthopedics 1998;6(4):13‐4.
Wang J 2008 {published data only}
-
- Wang J, Li WJ, Wang HY, Yang JY, Lin XS, Li A. Therapeutic effect observation of Ganshen Tongzhi method in treating postmenopausal osteoporosis in 38 cases. Journal of New Chinese Medicine 2008;40(6):54‐5.
Wang JH 2001 {published data only}
-
- Wang JH, Li ZG. The investigation on the treatment effect with osteoporosis by Qianggu pill. Hunan Guiding Journal of Traditional Chinese Medicine and Pharmacology 2001;7(5):243‐4.
Wang LM 2004 {published data only}
-
- Wang LM, Guo HS, Guo MX. Clinical observation on effect of Jiangu tang in treating 69 cases with senile osteoporosis. Chinese Journal of Clinical Practical Medicine 2004;5(11):103‐4.
Weng M 2003 {published data only}
-
- Weng M, Ai SC. Influence of medicine‐separated sticking on Shenque (RN8) on calcitonin in primary osteoporosis. Tianjin Journal of Traditional Chinese Medicine 2003;20(5):48‐9.
Wu CM 2004 {published data only}
-
- Wu CM, Zhang SQ, Zhang ZM. Clinical observation on effect of Bushen Zhuanggu capsule in treating osteoporosis. Journal of Sichuan Traditional Chinese Medicine 2004;22(2):76‐7.
Wu D 2008 {published data only}
-
- Wu D, Chen RH, Fang JL. Bushen Tiaogan method for patients with senile osteoporosis in 31 cases. Journal of Shandong University of Traditional Chinese Medicine 2008;32(2):126‐7.
Wu XG 2008 {published data only}
-
- Wu XG, Wu DH. Effects of Xianlinggubao, compound calcium amino acid chelate capsules and salcalcitonin in treating osteoporosis fracture. Chinese Journal of Traditional Medical Traumatology & Orthopedics 2008;16(4):20‐1.
Xia WF 2006 {published data only}
-
- Xia WF, Chen LL. Comparison of traditional Chinese medicine (Qianggu capsule) and risedronate sodium in management of postmenopausal osteoporosis. Chinese Journal of Osteoporosis 2006;12(4):393‐6.
Xie J 2001 {published data only}
-
- Xie J, Shen L, Yang YP, Zhou PQ, Gao L. The effect of Chinese traditional medicine of kidney invigoration on bone mass after Colles' fracture. Chinese Journal of Traditional Medical Traumatology & Orthopedics 2001;9(2):1‐3.
Xie J 2003 {published data only}
-
- Xie J, Shen L, Yang YP, Zhou PQ, Gao L. Clinical study on bone loss preventive effect of Chinese drugs for kidney‐tonifying in aged males. Chinese Journal of Integrated Traditional and Western Medicine 2003;23(1):4‐6.
Xu CY 2004 {published data only}
-
- Xu CY, Li BS, Xin BZ. Effect of the self‐made Bushen Jianpi Tongluo decoction on pain and bone mineral density of patients with osteoporosis. Chinese Journal of Clinical Rehabilitation 2004;8(30):6698‐9.
Xu LZ 2001 {published data only}
-
- Xu LZ, Hou BX, Shi Q, Xie KY. Analysis of the therapeutic effect of Yishen Zhuanggu granules on osteoporosis. Journal of Traditional Chinese Orthopedics and Traumatology 2001;13(9):9‐10.
Xu PH 2001 {published data only}
-
- Xu PH, Huang ZJ, Xiong FL, Zhang HM, Yu DK. Clinical study of Bushen Jiangu capsule in treating liver‐kidney deficiency osteoporosis. Traditional Chinese Drug Research & Clinical Pharmacology 2001;12(4):245‐7, 307.
Yang JP 2007 {published data only}
-
- Yang JP, Wang JB, Ding CG, Huo ST. Effect of Gushibao capsule on bone density and bone metabolism of osteoporosis. Hebei Journal of Traditional Chinese Medicine 2007;29(5):399‐400.
Yang WH 2010 {published data only}
-
- Yang WH, Shi X. Clinical study on Bushen Tongluo decoction plus western medicine in treating primary osteoporosis of kidney deficiency and blood‐stasis. Shanghai Journal of Traditional Chinese Medicine 2010;44(7):36‐7, 46.
Yan XP 2007 {published data only}
-
- Yan XP, Zhu JL, Yan Y, Kong WP, Lu P, Tao QW. Clinical study of Bushen Qiangdu recipe on 102 cases with ankylosing spondylitis, osteoporosis or osteopenia. China Journal of Traditional Chinese Medicine and Pharmacy 2007;22(8):571‐3.
Yu YH 2011 {published data only}
-
- Yu YH, Chen JY, Wang J. Effect of Erzhi pill on postmenopausal osteoporosis. Chinese Journal of Traditional Medical Traumatology & Orthopedics 2011;19(4):42‐3.
Zhang GM 2001 {published data only}
-
- Zhang GM, Guan SY, Wang WZ. Clinical study in postmenopausal osteoporosis treated with Xianguning powder. Acta Chinese Medicine and Pharmacology 2001;29(2):31‐2.
Zhang H 1999 {published data only}
-
- Zhang H, Wei ZY, Dong JW, Cui DZ, Cheng YC. Clinical observation on effect of Gubao capsule in treating primary osteoporosis. Journal of Traditional Chinese Orthopedics and Traumatology 1999;11(11):3‐4, 63.
Zhang WY 2005 {published data only}
-
- Zhang WY. Report of treating 45 cases of senile osteoporosis with Bupi Yishen Huoxue prescription. Gansu Journal of Traditional Chinese Medicine 2005;18(12):22‐3.
Zhao G 2004 {published data only}
-
- Zhao G, Xu ZL, Shao QX, Feng JL, Xue JP, Wang XG, et al. Comparison of tibolone tablets and kidney‐invigorating traditional Chinese medicine in prevention and treatment of postmenopausal osteoporosis. Chinese Journal of Osteoporosis 2004;10(3):337‐9.
Zhao Z 2010 {published data only}
-
- Zhao Z, Xiang K, Sun L. Clinical observation of 30 cases of primary osteoporosis in elderly people treated with Yanghe capsule. World Journal of Integrated Traditional and Western Medicine 2010;5(8):698‐700.
Zheng NX 2011 {published data only}
-
- Zheng NX, Zhang XH, Guo HM, Wang PC, Du HF, Guo HY, et al. Clinical observation of Duhuojishengtang on osteoporosis. Hebei Medicine 2011;17(2):225‐7.
Zheng XH 2004 {published data only}
-
- Zheng XH, Huang L. The clinical research of Gukangye on the primary osteoporosis. Chinese Journal of Traditional Medical Traumatology & Orthopedics 2004;12(3):20‐1.
Zheng ZW 2010 {published data only}
-
- Zheng ZW, Wang Z. Clinical observation of Bushenzhuanggu soup on primary osteoporosis. Family Medicine (Medical Tribune) 2010;2(7):516‐8. [DOI: 10.3969/j.issn.1671-4954.2010.07.030] - DOI
Zhong J 2010 {published data only}
-
- Zhong J, Tan SS, Xie LS. Zhuanggubushen decoction and acupuncture treat osteoporosis. Journal of Zhejiang University of Traditional Chinese Medicine 2010;34(3):408, 410.
Zhong RQ 2007a {published data only}
-
- Zhong RQ, Pan GM, Deng WM, Zhang GC. Clinical observation on effects of Gushenyijingtang in treating hip osteoporotic fractures. Chinese Journal of Traditional Medical Traumatology & Orthopedics 2007;15(7):50‐2.
Zhong RQ 2007b {published data only}
-
- Zhong RQ, Pan GM, Deng WM, Zhang GC. Clinical observation of Gushenyijing tang on treatment of thoracic vertebral compression osteoporotic fracture. Journal of South Medical University 2007;27(11):1724‐5.
Zhou PQ 1997 {published data only}
-
- Zhou PQ, Shen L, Yang YP, Xie J. Clinical study on effect of Migu tablet on postmenopausal osteoporosis. Chinese Journal of Traditional Medical Traumatology & Orthopedics 1997;15(1):20‐2.
Zhu LP 2008 {published data only}
-
- Zhu LP. Effect of Bushen Jianpi decoction on osteoporosis during climacteric. Zhejiang Journal of Integrated Traditional Chinese and Western Medicine 2008;18(3):139‐41.
Additional references
Altman 2003
Bengner 1988
-
- Bengner U, Johnell O, Redlund‐Johnell I. Changes in incidence and prevalence of vertebral fractures during 30 years. Calcified Tissue International 1988;42(5):293‐6. - PubMed
Cameron 2013
Chen 2012
Chen 2013
Cole 2008
-
- Cole ZA, Dennison EM, Cooper C. Osteoporosis epidemiology update. Current Rheumatology Reports 2008;10(2):92‐6. - PubMed
Confavreux 2012
-
- Confavreux CB, Canoui‐Poitrine F, Schott AM, Ambrosi V, Tainturier V, Chapurlat R. Persistence at 1 year of oral anti‐osteoporotic drugs: a prospective study in a comprehensive health insurance database. European Journal of Endocrinology 2012;166(4):735‐41. - PubMed
Cumming 1997
-
- Cumming RG, Nevitt MC, Cummings SR. Epidemiology of hip fractures. Epidemiologic Reviews 1997;19(2):244‐57. - PubMed
Diez 2002
-
- Diez F. Guidelines for the diagnosis of osteoporosis by densitometric methods. Journal of Manipulative and Physiological Therapeutics 2002;25(6):403‐15. - PubMed
Egger 2003
-
- Egger M, Juni P, Bartlett C, Holenstein F, Sterne J. How important are comprehensive literature searches and the assessment of trial quality in systematic reviews? Empirical study. Health Technology Assessment 2003;7(1):1‐76. - PubMed
Feng 2013
Flower 2012
Gan 2013
Genant 1999
-
- Genant HK, Cooper C, Poor G, Reid I, Ehrlich G, Kanis J, et al. Interim report and recommendations of the World Health Organization Task‐Force for Osteoporosis. Osteoporosis International 1999;10(4):259‐64. - PubMed
Gu 2013
Guo 2003a
-
- Guo SHF. Advances in treatment of osteoporosis (I). Modern Diagnosis & Treatment 2003;14(5):257‐62.
Guo 2003b
-
- Guo SHF. Advances in treatment of osteoporosis (II). Modern Diagnosis & Treatment 2003;14(6):321‐6.
Guo 2012
Haguenauer 2005
Higgins 2011
-
- Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane‐handbook.org. The Cochrane Collaboration.
Holroyd 2008
-
- Holroyd C, Cooper C, Dennison E. Epidemiology of osteoporosis. Best Practice & Research Clinical Endocrinology & Metabolism 2008;22(5):671‐85. - PubMed
Horst‐Sikorska 2011
-
- Horst‐Sikorska W, Wawrzyniak A. The role of hormonal therapy in osteoporosis. Endokrynologia Polska 2011;62(1):61‐4. - PubMed
Howe 2011
ICH GCP 1997
-
- International Conference on Harmonisation Expert Working Group. Code of Federal Regulations & International Conference on Harmonisation Guidelines. 1. Vol. 1, Pennsylvania: Parexel/Barnett, 1997.
IOF 2014
-
- International Osteoporosis Foundation. What is Osteoporosis?. http://www.iofbonehealth.org/what‐is‐osteoporosis.
Kushner 1998
-
- Kushner P. Osteoporosis: unmasking the silent epidemic. Hospital Medicine 1998;34:25‐39.
Leong 2002
-
- Leong KH. Medical treatment of osteoporosis‐‐increasing options. Annals of the Academy of Medicine, Singapore 2002;31(1):43‐7. - PubMed
Meng 2003
-
- Meng XD, Xie YM, Huang YZH, Cui TH, Gao R, Tu RSH, et al. Clinical study of Gu‐Jian capsule in treating primary osteoporosis with kidney‐yang deficiency syndrome. Chinese Journal of Clinical Rehabilitation 2003;7(3):445‐7, 457.
Moher 1998
-
- Moher D, Pham B, Jones A, Cook DJ, Jadad AR, Moher M, et al. Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta‐analyses. Lancet 1998;352(9128):609‐13. - PubMed
Nguyen 2000
-
- Nguyen TV, Center JR, Eisman JA. Association between breast cancer and bone mineral density: the Dubbo Osteoporosis Epidemiology Study. Maturitas 2000;36(1):27‐34. - PubMed
NOF 2014
-
- National Osteoporosis Foundation. What is Osteoporosis?. http://nof.org/articles/7.
Osteoporosis 1999
-
- Osteoporosis diagnostic criteria subject group in China. The Chinese diagnostic criteria of primary osteoporosis. Chinese Journal of Osteoporosis 1999;5(1):1‐3.
Qiu 2001
-
- Qiu GX. Osteoporosis and fracture. The First Countrywide Osteoporosis Academic Conference of China Medical Association. 2001:12‐9.
Raisz 2005
Rates 2001
-
- Rates SMK. Plants as source of drugs. Toxicon 2001;39(5):603‐13. - PubMed
RevMan 2012 [Computer program]
-
- The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
Rizzoli 2012
-
- Rizzoli R. Bisphosphonates treatment in patients with osteoporosis. Therapeutische Umschau. Revue Thérapeutique 2012;69(3):173‐81. - PubMed
Sambrook 2000
-
- Sambrook P, O'Neill S, Diamond T, Flicker L, MacLennan A. Postmenopausal osteoporosis treatment guidelines. Australian Family Physician 2000;29(8):756‐8. - PubMed
Schulz 1995
-
- Schulz KF, Chalmers I, Hayes R, Altman D. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 1995;273(5):408‐12. - PubMed
Silverman 2012
-
- Silverman S, Christiansen C. Individualizing osteoporosis therapy. Osteoporosis International 2012;23(3):797‐809. - PubMed
Vickers 1998
-
- Vickers A, Goyal N, Harland R, Rees R. Do certain countries produce only positive results? A systematic review of controlled trials. Controlled Clinical Trials 1998;19(2):159‐66. - PubMed
Wells 2008a
Wells 2008b
Wells 2008c
WHO 1994
-
- World Health Organization. Assessment of fracture risk and its application to screening postmenopausal osteoporosis. Report of a WHO Study Group. WHO Technical Report Series 843, 1994:1‐129. - PubMed
Winsloe 2009
-
- Winsloe C, Earl S, Dennison EM, Cooper C, Harvey NC. Early life factors in the pathogenesis of osteoporosis. Current Osteoporosis Reports 2009;7(4):140‐4. - PubMed
Woolf 2003
Wylie 2010
-
- Wylie CD. Setting a standard for a "silent" disease: defining osteoporosis in the 1980s and 1990s. Studies in History and Philosophy of Biological and Biomedical Sciences 2010;41(4):376‐85. - PubMed
Xia 2001
-
- Xia YX. Medicated diets therapy for osteoporosis. The First Countrywide Osteoporosis Academic Conference of China Medical Association. 2001:171‐2.
Xue 2000
-
- Xue Y. The retrospect and prospect of osteoporosis. New Century Seminar of Osteoporosis and Arthrosis Prospect and Constructing Convention of Osteoporosis and Osteoarthrosis of China Health Care Scientific and Technological College. 2000:1.
Yang 2013
Zhang 2012
Zhou 2001b
-
- Zhou LZH, Ma Y. Clinical examining of purgation‐tonifying therapy of Chinese traditional medicine on primary osteoporosis. Academic Seminar of Countrywide Osteoporosis and Osteoarthrosis. 2001:134‐9.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
