Modulatory role of D-chiro-inositol (DCI) on LH and insulin secretion in obese PCOS patients

Gynecol Endocrinol. 2014 Jun;30(6):438-43. doi: 10.3109/09513590.2014.897321. Epub 2014 Mar 7.


Polycystic ovary syndrome (PCOS) is a common endocrine condition that affects fertility through oligo-ovulation, hyperandrogenism and polycystic morphology of the ovaries. Since it has been demonstrated a high incidence of insulin resistance in PCOS patients, our study aimed to evaluate the efficacy of the integrative treatment with D-chiro-inositol (DCI) (500 mg die, per os, for 12 weeks) on hormonal parameters and insulin sensitivity in a group of overweight/obese PCOS patients (body mass index; BMI > 26). After the treatment, interval several endocrine parameters improved (luteinizing hormone [LH], LH/follicle stimulating hormone [FSH], androstenedione and insulin), insulin response to oral glucose tolerance test reported the significant improvement of insulin sensitivity as well as the gonadotropin-releasing hormone (GnRH)-induced (10 µg, in bolus) LH response. BMI decreased, though no lifestyle modification was requested. When data were analyzed according to the presence or absence of first-grade diabetic relatives, PCOS patients with diabetic relatives showed greater improvement after DCI administration. In conclusion DCI administration is effective in restoring better insulin sensitivity and an improved hormonal pattern in obese hyperinsulinemic PCOS patients, in particular, in hyperinsulinemic PCOS patients who have diabetic relatives.

Keywords: Body mass index; insulin resistance; insulin sensitizer; polycystic ovary syndrome.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Body Mass Index
  • Dietary Supplements*
  • Family Health
  • Female
  • Gonadotropin-Releasing Hormone
  • Humans
  • Hyperinsulinism / etiology
  • Hyperinsulinism / prevention & control
  • Hypoglycemic Agents / chemistry
  • Hypoglycemic Agents / therapeutic use
  • Inositol / chemistry
  • Inositol / therapeutic use*
  • Insulin / blood
  • Insulin / metabolism
  • Insulin Resistance
  • Insulin Secretion
  • Insulin-Secreting Cells / metabolism*
  • Italy
  • Luteinizing Hormone / blood
  • Luteinizing Hormone / metabolism*
  • Obesity / complications*
  • Overweight / complications
  • Pituitary Gland, Anterior / metabolism*
  • Pituitary Gland, Anterior / physiopathology
  • Polycystic Ovary Syndrome / blood
  • Polycystic Ovary Syndrome / complications
  • Polycystic Ovary Syndrome / diet therapy*
  • Polycystic Ovary Syndrome / physiopathology
  • Stereoisomerism


  • Hypoglycemic Agents
  • Insulin
  • Gonadotropin-Releasing Hormone
  • Inositol
  • Luteinizing Hormone