Axon guidance: FLRTing promotes attraction

Curr Biol. 2014 Mar 3;24(5):R198-200. doi: 10.1016/j.cub.2014.01.038.


A recent study demonstrates a new mechanism by which crosstalk between multiple guidance cues is integrated during axon pathfinding. FLRT3 is a novel co-receptor for Robo1 that acts as a context-dependent modulator of Netrin-1 attraction in thalamocortical axons.

Publication types

  • Comment

MeSH terms

  • Animals
  • Axons / physiology*
  • Membrane Glycoproteins / metabolism*
  • Nerve Growth Factors / metabolism*
  • Nerve Tissue Proteins / metabolism*
  • Netrin-1
  • Receptors, Immunologic / metabolism*
  • Tumor Suppressor Proteins / metabolism*


  • FLRT3 protein, mouse
  • Membrane Glycoproteins
  • Nerve Growth Factors
  • Nerve Tissue Proteins
  • Ntn1 protein, mouse
  • Receptors, Immunologic
  • Tumor Suppressor Proteins
  • roundabout protein
  • Netrin-1