Aging: it's SIRTainly possible to restore mitochondrial dysfunction

Brooke E Christian; Gerald S Shadel

doi:10.1016/j.cub.2014.01.027

Aging: it's SIRTainly possible to restore mitochondrial dysfunction

Curr Biol. 2014 Mar 3;24(5):R206-8. doi: 10.1016/j.cub.2014.01.027.

Authors

Brooke E Christian¹, Gerald S Shadel²

Affiliations

¹ Departments of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.
² Departments of Pathology, Yale School of Medicine, New Haven, CT 06520, USA; Genetics, Yale School of Medicine, New Haven, CT 06520, USA. Electronic address: Gerald.Shadel@yale.edu.

PMID: 24602889
DOI: 10.1016/j.cub.2014.01.027

Abstract

Mitochondrial dysfunction is strongly associated with aging. A recent study shows that reduced nuclear SIRT1 activity initiates age-related mitochondrial decline through a signaling pathway that perturbs expression of genes encoded by mitochondrial DNA. This reversible pathway has potential anti-aging therapeutic value.

Publication types

Comment

MeSH terms

Aging / pathology*
Animals
Cell Nucleus / metabolism*
Mitochondria / metabolism*
NAD / metabolism*
Oxidative Phosphorylation*

Substances

NAD

Grants and funding

F32 NS077723/NS/NINDS NIH HHS/United States