Aging: it's SIRTainly possible to restore mitochondrial dysfunction

Curr Biol. 2014 Mar 3;24(5):R206-8. doi: 10.1016/j.cub.2014.01.027.


Mitochondrial dysfunction is strongly associated with aging. A recent study shows that reduced nuclear SIRT1 activity initiates age-related mitochondrial decline through a signaling pathway that perturbs expression of genes encoded by mitochondrial DNA. This reversible pathway has potential anti-aging therapeutic value.

Publication types

  • Comment

MeSH terms

  • Aging / pathology*
  • Animals
  • Cell Nucleus / metabolism*
  • Mitochondria / metabolism*
  • NAD / metabolism*
  • Oxidative Phosphorylation*


  • NAD