[Protective effect of selank on the model of mnestic function violation induced by pharmacological blockade of protein synthesis]

Eksp Klin Farmakol. 2013;76(12):3-7.
[Article in Russian]

Abstract

We have studied the ability of peptide anxiolytic selank (Thr-Lyz-Pro-Arg-Pro-Gly-Pro) to compensate for mnestic dysfunction caused by the administration of actinomycin D, which inhibits protein synthesis by blocking DNA-dependent RNA polymerase. The experiments were performed on white rats with acquired adaptive ability of spatial visual orientation in a 16-door labyrinth. The learning was based on the avoidance of electric skin irritation at alternating sites of escape reaction (site reflex). Selank (0.5 mg/kg, i.p.) prevented or compensated for actinomycin D (250 mg/kg, i.p.) induced violation of the process of acquisition, improvement, and consolidation of memory trace during the development of a complex site reflex. The drug administration also reduced the time required for acquisition of the adaptive ability of spatial visual orientation in the labyrinth and restored the actinomycin D violated process of re-learning upon a change in the alternation of escape sites under free-choice conditions.

MeSH terms

  • Animals
  • Dactinomycin / adverse effects
  • Dactinomycin / pharmacology
  • Male
  • Maze Learning / drug effects*
  • Oligopeptides / pharmacology*
  • Protein Biosynthesis / drug effects*
  • Protein Synthesis Inhibitors / adverse effects
  • Protein Synthesis Inhibitors / pharmacokinetics
  • Rats
  • Visual Perception / drug effects*

Substances

  • Oligopeptides
  • Protein Synthesis Inhibitors
  • Dactinomycin
  • TP 7