Effect of Low-Fat Diet on Breast Cancer Survival: A Meta-Analysis

Asian Pac J Cancer Prev. 2014;15(3):1141-4. doi: 10.7314/apjcp.2014.15.3.1141.


Background: Even though many studies have examined the possible effect of low-fat diet on breast cancer survival, the relationship remains unclear.

Objectives: To summarize the current evidence about the effect of post-diagnostic low-fat diet on recurrence and all-cause mortality of breast cancer.

Methods: We conducted a search of Pubmed, Embase, Web of Science, and Cochrane Library and as a result two randomized controlled trials (RCT) and one large multi-center prospective cohort study with 9,966 breast cancer patients were included in this report.

Results: Post-diagnostic low-fat diet reduced risk of recurrence of breast cancer by 23% (HR=0.77, 95%CI 0.63 to 0.94, P=0.009) and all cause mortality of breast cancer by 17% (HR=0.83, 95%CI 0.69 to 1.00, P=0.05).

Conclusions: This meta-analysis suggested the post-diagnostic low-fat diet can improve breast cancer survival by reducing risk of recurrence. However, more trials of the relationship between low-fat diet and all- cause mortality of breast cancer are still needed.

Publication types

  • Meta-Analysis

MeSH terms

  • Breast Neoplasms / diet therapy*
  • Breast Neoplasms / mortality*
  • Diet, Fat-Restricted*
  • Female
  • Humans
  • Neoplasm Recurrence, Local / diet therapy*
  • Treatment Outcome