Myelin-associated inhibitors in axonal growth after CNS injury

Curr Opin Neurobiol. 2014 Aug;27:31-8. doi: 10.1016/j.conb.2014.02.012. Epub 2014 Mar 6.

Abstract

There are multiple barriers to axonal growth after CNS injury. Myelin-associated inhibitors represent one group of barriers extrinsic to the injured neurons. Nogo, MAG and OMgp are three prototypical myelin inhibitors that signal through multiple neuronal receptors to exert growth inhibition. Targeting myelin inhibition alone modulates the compensatory sprouting of uninjured axons but the effect on the regeneration of injured axons is limited. Meanwhile, modulating sprouting, a naturally occurring repair mechanism, may be a more attainable therapeutic goal for promoting functional repair after CNS injury in the near term.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Axons / physiology*
  • Central Nervous System Diseases / physiopathology*
  • Central Nervous System Diseases / therapy*
  • Humans
  • Myelin Proteins / metabolism
  • Myelin Sheath / metabolism*
  • Myelin-Associated Glycoprotein / metabolism
  • Nerve Regeneration / physiology*
  • Nogo Proteins
  • Oligodendrocyte-Myelin Glycoprotein / metabolism

Substances

  • Myelin Proteins
  • Myelin-Associated Glycoprotein
  • Nogo Proteins
  • Oligodendrocyte-Myelin Glycoprotein
  • RTN4 protein, human