Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: a randomized clinical trial

Chin J Integr Med. 2014 May;20(5):347-52. doi: 10.1007/s11655-014-1804-8. Epub 2014 Mar 7.

Abstract

Objective: It has been proposed that royal jelly has antioxidant properties and may improve oxidative stress and glycemic control. Therefore, we investigated the effects of royal jelly supplementation in diabetic females.

Methods: In this pilot, parallel design randomized clinical trial, 50 female volunteers with type 2 diabetes were randomly allocated to the supplemented (25, cases) and placebo (25, cases) groups, based on random block procedure produced by Random Allocation Software, given a daily dose of 1,000 mg royal jelly soft gel or placebo, respectively, for 8 weeks. Before and after intervention, glycemic control indices, antioxidant and oxidative stress factors were measured.

Results: After royal jelly supplementation, the mean fasting blood glucose decreased remarkably (163.05±42.51 mg/dL vs. 149.68±42.7 mg/dL). Royal jelly supplementation resulted in significant reduction in the mean serum glycosylated hemoglobin levels (8.67%±2.24% vs. 7.05%±1.45%, P=0.001) and significant elevation in the mean insulin concentration (70.28±29.16 pmol/L vs. 86.46±27.50 pmol/L, P=0.01). Supplementation significantly increased erythrocyte superoxidase dismutase and glutathione peroxidase activities and decreased malondialdehyde levels (P<0.05). At the end of study, the mean total antioxidant capacity elevated insignificantly in both groups.

Conclusions: On the basis of our findings, it seems that royal jelly supplementation may be beneficial in controlling diabetes outcomes. Further studies with larger sample size are warranted.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Glucose / metabolism*
  • Diabetes Mellitus, Type 2 / metabolism
  • Diabetes Mellitus, Type 2 / therapy*
  • Fatty Acids*
  • Female
  • Glutathione Peroxidase / blood
  • Glycated Hemoglobin A / metabolism
  • Humans
  • Malondialdehyde / metabolism
  • Oxidative Stress*
  • Pilot Projects
  • Placebos
  • Superoxide Dismutase / blood

Substances

  • Blood Glucose
  • Fatty Acids
  • Glycated Hemoglobin A
  • Placebos
  • hemoglobin A1c protein, human
  • Malondialdehyde
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • royal jelly