Protective effect of curcumin against contrast induced nephropathy in rat kidney: what is happening to oxidative stress, inflammation, autophagy and apoptosis?

Eur Rev Med Pharmacol Sci. 2014;18(4):461-70.


Background: Currently, the number of imaging and interventional procedures that use contrast agents (CAs) is gradually increasing. Oxidative stress plays a significant role in its pathophysiology. Curcumin (CC) is a natural substance with strong antioxidant efficacy.

Materials and methods: In total, 24 male Wistar-albino rats were divided into four groups with seven rats in each group.

Results: Biochemical measurements showed a significant increase (p < 0.001) in urea, creatinine and malondialdehyde (MDA) but a significant decrease (p < 0.001) in glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) levels in the contrast-induced nephropathy (CIN) group compared with the control group. The immunohistochemical examination revealed a significant increase in autophagic and apoptotic cell death ratios and in the inflammatory signal (p < 0.05). Compared with the CIN group, a significant improvement in these unfavorable parameters was observed with CC therapy.

Conclusions: The preventive efficacy of CC against an experimental model of CIN has been demonstrated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Antioxidants / pharmacology*
  • Apoptosis / drug effects*
  • Autophagy / drug effects*
  • Biomarkers / metabolism
  • Contrast Media*
  • Curcumin / pharmacology*
  • Cytoprotection
  • Disease Models, Animal
  • Iopamidol / analogs & derivatives*
  • Kidney / drug effects*
  • Kidney / metabolism
  • Kidney / pathology
  • Kidney Diseases / chemically induced
  • Kidney Diseases / metabolism
  • Kidney Diseases / pathology
  • Kidney Diseases / prevention & control*
  • Male
  • Nephritis / chemically induced
  • Nephritis / metabolism
  • Nephritis / pathology
  • Nephritis / prevention & control*
  • Oxidative Stress / drug effects*
  • Rats, Wistar


  • Anti-Inflammatory Agents
  • Antioxidants
  • Biomarkers
  • Contrast Media
  • iomeprol
  • Curcumin
  • Iopamidol