Periodontal ligament stem cells: an update and perspectives

J Investig Clin Dent. 2014 May;5(2):81-90. doi: 10.1111/jicd.12089. Epub 2014 Mar 7.


Chronic periodontitis is a serious infectious and inflammatory oral disease of humans worldwide. Conventional treatment modalities are effective for controlling periodontal disease. However, the regeneration of damaged periodontal tissues remains a major challenge in clinical practice due to the complex structure of the periodontium. Stem cell-based regenerative approaches combined with the usage of emerging biomaterials are entering a new era in periodontal regeneration. The present review updates the current knowledge of periodontal ligament stem cell-based approaches for periodontal regeneration, and elaborates on the potentials for clinical application.

Keywords: chronic periodontitis; periodontal disease; periodontal ligament stem cells; regeneration; tissue engineering.

Publication types

  • Review

MeSH terms

  • Biocompatible Materials / therapeutic use
  • Chronic Periodontitis / therapy
  • Guided Tissue Regeneration, Periodontal / methods
  • Humans
  • Multipotent Stem Cells / physiology
  • Periodontal Ligament / cytology*
  • Stem Cells / physiology*
  • Tissue Scaffolds / chemistry


  • Biocompatible Materials