Etanercept - TNF receptor and IgG1 Fc fusion protein: is it different from other TNF blockers?

Expert Opin Biol Ther. 2014 May;14(5):569-72. doi: 10.1517/14712598.2014.896334. Epub 2014 Mar 10.


TNF blockers have been available to treat various inflammatory disorders since more than a decade. T cells and macrophages mainly express TNF and activate many cells through two types of receptors. Pharmaceutical companies developed two types of TNF blockers: soluble receptors and monoclonal antibodies. Understanding of differences of structure and function can explain divergence of efficacy or side effects. Etanercept has the best retention rate in rheumatic diseases, but is less or not effective in granulomatous diseases, such as inflammatory bowel diseases or uveitis. However, etanercept induces less tuberculosis infections than anti-TNF blocker monoclonal antibodies.

Publication types

  • Editorial

MeSH terms

  • Antibodies, Neutralizing / biosynthesis
  • Etanercept
  • Humans
  • Immunoglobulin G / chemistry*
  • Immunoglobulin G / pharmacology
  • Receptors, Tumor Necrosis Factor / chemistry*
  • Recombinant Fusion Proteins / pharmacology*
  • Recombinant Fusion Proteins / therapeutic use
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors*


  • Antibodies, Neutralizing
  • Immunoglobulin G
  • Receptors, Tumor Necrosis Factor
  • Recombinant Fusion Proteins
  • Tumor Necrosis Factor-alpha
  • Etanercept