Antinociceptive effect of chlorogenic acid in rats with painful diabetic neuropathy

J Med Food. 2014 Jun;17(6):730-2. doi: 10.1089/jmf.2013.2966. Epub 2014 Mar 10.


The present study aimed to evaluate possible antinociceptive effects of chlorogenic acid in streptozotocin-induced diabetic neuropathic pain in rats. Chlorogenic acid (100 mg/kg) was administered daily for 14 days. Our study showed for the first time that both single and chronic chlorogenic acid treatments produced significant antinociceptive effects in diabetic rats. In contrast, single dose of chlorogenic acid showed no signs of an antinociceptive effect, but chronic treatment exerted antinociceptive potential in nondiabetic rats. Additionally, chronic treatment effectively reduced hyperglycemia that induced by diabetes. In conclusion, chlorogenic acid has beneficial effects for the management of diabetic neuropathic pain.

Keywords: antihyperalgesic; antinociceptive; chlorogenic acid; diabetes; diabetic neuropathy; pain.

MeSH terms

  • Analgesics / pharmacology
  • Analgesics / therapeutic use*
  • Animals
  • Chlorogenic Acid / pharmacology
  • Chlorogenic Acid / therapeutic use*
  • Diabetes Mellitus, Experimental / complications*
  • Diabetic Neuropathies / drug therapy*
  • Hyperglycemia / drug therapy
  • Hypoglycemic Agents / pharmacology
  • Hypoglycemic Agents / therapeutic use
  • Male
  • Phytotherapy*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Rats, Wistar


  • Analgesics
  • Hypoglycemic Agents
  • Plant Extracts
  • Chlorogenic Acid