Role of prolactin in B cell regulation in multiple sclerosis

J Neuroimmunol. 2014 Apr 15;269(1-2):76-86. doi: 10.1016/j.jneuroim.2014.02.007. Epub 2014 Feb 24.

Abstract

The role of prolactin in MS pathogenesis was investigated. Prolactin levels were higher in MS subjects both during remission and exacerbation compared to control subjects. Prolactin increased JAK2 expression and Stat phosphorylation on B cells, up-regulated anti-MOG antibody secreting cell numbers, BAFF levels, and Bcl-2expression, and down-regulated expression of Trp63. Prolactin levels correlated positively with anti-MOG secreting cell numbers, and negatively with induced apoptotic B cells. Additionally, prolactin decreased B cell receptor-mediated activation threshold, and induced CD40 expression in B cells. These findings suggest that prolactin promotes B cell autoreactivity in MS through different mechanisms.

Keywords: Autoimmunity; B cells; Hormones; Multiple sclerosis; Prolactin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • B-Lymphocytes / physiology*
  • Biomarkers / blood
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis / blood
  • Multiple Sclerosis / diagnosis
  • Multiple Sclerosis, Relapsing-Remitting / blood*
  • Multiple Sclerosis, Relapsing-Remitting / diagnosis*
  • Prolactin / blood
  • Prolactin / physiology*

Substances

  • Biomarkers
  • Prolactin