A case of harlequin ichthyosis treated with isotretinoin

Dermatol Online J. 2014 Feb 18;20(2):doj_21540.


Harlequin ichthyosis is a rare congenital ichthyosis classified under the category of Autosomal Recessive Congenital Ichthyoses, which also include lamellar ichthyosis and congenital ichthyosiform erythroderma. It is caused by functional null mutations in the ABCA12 gene, a keratinocyte lipid transporter associated with lamellar granule formation. Patients have a classic clinical presentation at delivery and need neonatal intensive care treatment to maximize their chances of survival. Early oral retinoid therapy has been shown to increase survival in patients with harlequin ichthyosis, and we present a case of a 9-month-old male with this condition who has been treated with isotretinoin since day 7 of life.

Publication types

  • Case Reports

MeSH terms

  • Humans
  • Ichthyosis, Lamellar / drug therapy*
  • Ichthyosis, Lamellar / therapy
  • Infant
  • Infant, Newborn
  • Isotretinoin / therapeutic use*
  • Keratolytic Agents / therapeutic use*
  • Male


  • Keratolytic Agents
  • Isotretinoin

Supplementary concepts

  • Harlequin type ichthyosis