Defining prostate cancer risk after radical prostatectomy

Eur J Surg Oncol. 2014 May;40(5):496-504. doi: 10.1016/j.ejso.2014.02.221. Epub 2014 Feb 20.

Abstract

Prostate cancer encompasses a wide spectrum of tumor phenotypes with differing prognoses and a part of these patients are at risk of experiencing tumor recurrence after initial treatment. This review discusses the parameters that determine PCa risk for failure after radical prostatectomy and also focuses on the ability of currently available post-treatment nomograms to predict treatment outcomes, and probability of treatment failure. The use of predictive nomograms may be therefore helpful in the complex decision making process.

Keywords: Adverse features; Predictive nomograms; Prostate cancer; Radical prostatectomy.

Publication types

  • Review

MeSH terms

  • Carcinoma / pathology
  • Carcinoma / surgery*
  • Humans
  • Kallikreins / metabolism
  • Male
  • Neoplasm Grading
  • Neoplasm Invasiveness
  • Neoplasm Recurrence, Local*
  • Nomograms*
  • Prognosis
  • Prostate-Specific Antigen / metabolism
  • Prostatectomy*
  • Prostatic Neoplasms / pathology
  • Prostatic Neoplasms / surgery*
  • Risk Assessment / methods*
  • Treatment Failure

Substances

  • KLK3 protein, human
  • Kallikreins
  • Prostate-Specific Antigen