Preliminary evidence that early reduction in p11 levels in natural killer cells and monocytes predicts the likelihood of antidepressant response to chronic citalopram

Mol Psychiatry. 2014 Sep;19(9):962-4. doi: 10.1038/mp.2014.13. Epub 2014 Mar 11.

Abstract

The prediction of treatment response in many neuropsychiatric disorders would be facilitated by easily accessible biomarkers. Using flow cytometry, we herein demonstrate correlations between early reductions of p11 levels in Natural Killer (NK) cells and monocytes and antidepressant response to citalopram in patients with major depressive disorder (MDD).

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Annexin A2 / metabolism*
  • Antidepressive Agents / therapeutic use*
  • Biomarkers, Pharmacological / metabolism
  • Citalopram / therapeutic use*
  • Depressive Disorder, Major / drug therapy*
  • Depressive Disorder, Major / metabolism
  • Female
  • Flow Cytometry
  • Humans
  • Killer Cells, Natural / metabolism*
  • Male
  • Monocytes / metabolism*
  • S100 Proteins / metabolism*

Substances

  • Annexin A2
  • Antidepressive Agents
  • Biomarkers, Pharmacological
  • S100 Proteins
  • S100 calcium binding protein A10
  • Citalopram