Ropinirole-induced Pisa syndrome in Parkinson disease

Clin Neuropharmacol. 2014 Mar-Apr;37(2):58-9. doi: 10.1097/WNF.0000000000000022.


Pisa syndrome (PS), also known as pleurothotonus, is an abnormal posture characterized by lateral flexion of the trunk that typically disappears in supine position. In Parkinson disease (PD), an abnormal forward flexion of the trunk (defined as camptocormia) is a common observation and has been interpreted as a sign of dystonia. Few reports have described PS mainly related to dopaminergic therapy in this kind of patients.Levodopa/carbidopa, levodopa/benserazide, levodopa/carbidopa/entacapone, pergolide, and pramipexole may cause PS, whereas no reports for ropinirole have been described.Here, we describe a case of a patient with PD who developed severe and reversible PS due to ropinirole intake.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Dopamine Agonists / adverse effects*
  • Dopamine Agonists / therapeutic use
  • Dystonia / chemically induced*
  • Female
  • Humans
  • Indoles / adverse effects*
  • Indoles / therapeutic use
  • Parkinson Disease / complications*
  • Parkinson Disease / drug therapy
  • Syndrome


  • Dopamine Agonists
  • Indoles
  • ropinirole