Background: A report of multiple cases of bile duct cancer at a Japanese printing company raised concern about such cancers. We examined long-term trends in bile duct cancer in Japan.
Methods: Data from 4 population-based cancer registries were used to calculate incidence between 1985 and 2007, and vital statistics were used to estimate mortality between 1985 and 2011. Age-standardized rates were calculated and analyzed using a joinpoint regression model.
Results: Among men, the incidence rate of intrahepatic bile duct cancer increased throughout the observation period; among women, it increased until 1996-1998 and remained stable thereafter. The incidence rate of extrahepatic bile duct cancer was stable in men and decreased from 1993-1995 in women. In people aged 30 to 49 years, the incidence rates of intra- and extrahepatic bile duct cancer remained stable or decreased. The mortality rate of intrahepatic bile duct cancer increased in both sexes and in all age groups since 1996, while that of extrahepatic bile duct cancer decreased since 1992. In people aged 30 to 49 years, the mortality rates of intra- and extrahepatic bile duct cancer remained stable and decreased, respectively.
Conclusions: The incidence and mortality rates of intrahepatic bile duct cancer remained stable or increased throughout the observation period. The incidence rate of extrahepatic bile duct cancer remained stable or decreased, and the mortality rate decreased since 1992. In people aged 30 to 49 years, the incidence and mortality rates of intra- and extrahepatic bile cancer remained stable or decreased.
【背景】: 印刷会社における胆管がんの多発が報告され、関心が高まっている。本研究では、日本における胆管がんの長期トレンドを検討した。
【方法】: がん罹患は1985–2007年の4つの地域がん登録、がん死亡は1985–2011年の人口動態統計を用いた。年齢調整率はJoinpoint回帰モデルを用いて解析した。
【結果】: 全年齢の肝内胆管がんの罹患率は、男性では観察期間中増加し、女性では1996–1998年まで増加し、それ以降は一定であった。肝外胆管がんの罹患率は、男性では一定で、女性では1993–1995年から減少した。30–49歳の肝内胆管と肝外胆管の罹患率は、一定または減少した。男女共に肝内胆管がんの死亡率は1996年から増加し、肝外胆管の死亡率は1992年から減少した。30–49歳の肝内胆管の死亡率は一定で、肝外胆管の死亡率は減少した。
【結論】: 肝内胆管がんの罹患率と死亡率は、観察期間中一定か増加していた。一方、肝外胆管がんの罹患率は一定か減少で、死亡率は1992年から減少していた。30–49歳では、肝内胆管と肝外胆管の罹患率と死亡率は一定か減少していた。